Stress among nurses is still perceived as a challenge experienced by the nursing profession. Stress has the negative impact on both nurses and patients. This book entitled:Exploring the factors contributing to nurses' stress and related coping strategies at selected Hospital in East Africa/Case of Rwanda is aimed to help nurses to identify their stressors and related coping strategies in order to contribute to the delivery of quality nursing cares.It can be inferred that nurses' stressors need to be addressed in order to create a working environment conducive to high quality of care in health sector.