Nutriose-Eudragit Coated Pellets For Colon Targeted Drug Delivery - Mittal, Ashu;Ghosh, Debaprasad;Singh, Pravin Kumar
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Multiparticulate drug delivery systems are consists of multiple small discrete units. They are mainly oral dosage forms. Each individual small discrete unit exhibit same desired characteristics. In the multiparticulate systems, the dosage of the drug substances is distributed on a plurality of subunit, namely consisting of thousands of spherical particles with diameter of 0.05-2.00mm. Thus the multiparticulate dosage forms are the pharmaceutical formulations in which the active substance API is present as a number of small independent subunits. For the delivery of the recommended total dose,…mehr

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Produktbeschreibung
Multiparticulate drug delivery systems are consists of multiple small discrete units. They are mainly oral dosage forms. Each individual small discrete unit exhibit same desired characteristics. In the multiparticulate systems, the dosage of the drug substances is distributed on a plurality of subunit, namely consisting of thousands of spherical particles with diameter of 0.05-2.00mm. Thus the multiparticulate dosage forms are the pharmaceutical formulations in which the active substance API is present as a number of small independent subunits. For the delivery of the recommended total dose, these subunits are filled into a sachet or into a capsule and encapsulated or compressed into a tablet and then administered in to the patient. Multiparticulates comprises of discrete particles , so they are called multipleunit system. As they have small size , so they have many advantages over single-unit systems e.g., multiparticulates are less dependent on gastric emptyting, resulting in less inter and intra-subject variability in gastrointestinal transit time.
Autorenporträt
Dieses Buch bietet einen umfassenden Überblick über das systematische Verfahren zur Erstellung und Validierung einer IVIVC. Es beschreibt die Entwicklung der IVIVC als ein Werkzeug, das während und nach der Entwicklung von Formulierungen mit verlängerter Freisetzung Zeit und Kosten sparen kann. Außerdem werden die biopharmazeutischen, pharmakokinetischen und mathematischen Aspekte bei der Entwicklung von ER-Produkten erörtert.