Nutrition in Epigenetics

Herausgeber: Niculescu, Mihai D; Haggarty, Paul

• Gebundenes Buch

Produktbeschreibung

The study of epigenetics, or how heritable changes in gene expression are regulated without modifying the coding DNA sequence, has become an increasingly important field of study in recent years. Rapid developments in our understanding of the way in which gene function is modulated by the environment has revolutionized the way we think about human development and health. Nutrition in Epigenetics reviews the latest research looking at the interaction between genes and nutrients and the role they play together in maintaining human health. Nutrition in Epigenetics is divided into two primary parts. The first part provides key principles such as epigenetic mechanisms, developmental epigenetics, and the role of epigenetics in disease. The second part looks specifically at the application of epigenetics to the field of human nutrition. Chapters review the role of specific nutrients in modulating epigenetic status and the effect on health and disease. Nutrition in Epigenetics is an indispensable resource for researchers, professionals and advanced students with an interest in human nutrition, epigenetics, and biomedical research.

---

Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.

Produktdetails

• Verlag: Wiley
• Seitenzahl: 384
• Erscheinungstermin: 28. Juni 2011
• Englisch
• Abmessung: 246mm x 173mm x 23mm
• Gewicht: 885g
• ISBN-13: 9780813816050
• ISBN-10: 081381605X
• Artikelnr.: 33278204

Autorenporträt

Mihai D. Niculescu is an Assistant Professor of Nutrition at the University of North Carolina's Gillings School of Global Public Health in Chapel Hill, and at the UNC Nutrition Research Institute in Kannapolis, North Carolina, USA. Paul Haggarty is Head of the Lifelong Health Programme, and the Nutrition and Epigenetics Group, at the Rowett Institute of Nutrition and Health in the University of Aberdeen in Aberdeen, Scotland.

Inhaltsangabe

Contributors vii
1. Introduction 1
Mihai D. Niculescu and Paul Haggarty
Part I: Fundamental Principles in Epigenetics
Section A: Epigenetic Mechanisms
2. DNA Methylation 13
Natalia V. Cucu
3. Chromatin Modifications 47
Sandra B. Hake
4. Roles of RNAi and Other Micro-RNAs in the Regulation of Epigenetic
Processes 73
Muller Fabbri
5. Epigenetic Inheritance: Both Mitotic and Meiotic 87
Nina J. Kaminen-Ahola, Arttu I. Ahola, and Emma Whitelaw
Section B: Development Epigenetics
6. Developmental Epigenetics: Roles in Embryonic Development 107
Liliana Burlibas¿a and Lucian Gavrila
Section C: Epigenetic Mechanisms in Disease
7. Epigenetics, Nutrition, and Cancer 129
Amy R. Johnson
8. Metabolic Syndrome, Obesity, and Diabetes 145
Karen D. Corbin
9. Autoimmunity 165
Donna Ray and Raymond Yung
10. Cardiovascular Diseases 173
Aurelian Bidulescu and Methode Bacanamwo
Part II: Nutritional Status and Specific Nutrients
Section A: Maternal Nutrition and Fetal Development
11. Maternal Nutrition and Developmental Outcomes 193
Shannon L. Haley, Laurie J. Moyer-Mileur, Robert H. Lane, and Lisa A.
Joss-Moore
Section B: Role of Specific Nutrients
12. Folate, Vitamin B12, and Vitamin B6 211
Patrick J. Stover
13. Dietary Choline, Betaine, Methionine, and Epigenetic Mechanisms
Influencing Brain Development 225
Steven H. Zeisel
14. Epigenetic Regulation by Retinoids 241
Amandio Vieira
15. We Are What We Eat: How Nutritional Compounds Such As Isoflavones Shape
Our Epigenome 249
Carlos M. Guerrero-Bosagna and Susan J. Clark
16. Isothiocyanates and Polyphenols 263
Nigel J. Belshaw and Ian T. Johnson
Section C: Macronutrient Intakes
17. The Effect of Maternal Macronutrient Intake on Phenotype Induction and
Epigenetic Gene Regulation 275
Karen A. Lillycrop, Mark A. Hanson, and Graham C. Burdge
Section D: Environmental Exposures
18. Epigenetic Manifestation of Environmental Exposures 289
Dana C. Dolinoy, Olivia S. Anderson, and Laura S. Rozek
Section E: Epidemiology of Nutritional Epigenetics
19. Epigenetics, Nutrition, and Reproduction: Short- and Long-Term
Consequences 311
Paul Haggarty
20. Nutrition, Epigenetics, and Cancer: An Epidemiological Perspective 329
Audrey Jung and Ellen Kampman
Index 345