O Brother! is a fraternal call to all fellow humans for knowledge, love, purity of intention, avoidance from evil deeds and attaining spiritual purity through compunction, contrition, pledge to stay pious, tenaciously holding fast to the cause of good. This book demystifies suspicions and doubts about man's instinctual behaviour in society. We are to grow physically, spiritually, socially, morally and culturally. The human apparatus is designed to take us along the right path of instinctual growth. We all are blessed with aptitude and proclivity for piety and righteousness. That is the instinct God has created us with. Whatever permissible profession we enter, God provides us ample chances to stick to the right path and stay far from wrong. The only criterion is to follow what the attributes of God lead us to.