The aim of this study was to investigate the occupational safety knowledge and practices of employees in four table water manufacturing companies in Obio/Akor LGA of Rivers State. Eight research questions and six hypotheses were formulated to achieve the aim of the study. The study adopted a descriptive survey design with a population which consisted of all the 1001 employees. A proportionate random sampling technique was sued to select a sample size of 517. The instrument for data collection was a structured questionnaire with a reliability index of 0.74. Data collected was analyzed using Statistical Package for Social Science (SPSS) verson 20. Statistical tools such as frequency count, percentage, means, Pearson Correlation and ANOVA were used to analyze the data generated. The findings of the study showed that, about three quarter (74.5%) of the respondents had a good knowledge of occupational safety. Overall, about half 229 (50.25) of the respondents practice occupational safety always, 107 (23.5%) practiced occasionally, 63(13.8%) hardly while 57(12.5) never practiced occupational safety.