A cyst is a pathological cavity or sac within the hard or soft tissues that may contain fluid, semi fluid or gas. It may be lined be epithelium, fibrous tissue or occasionally even by neoplastic tissue. Odontogenic Keratocyst has always been a controversial topic in oral and maxillofacial surgery. This book attempts to review the literature with basic focus on the origin, clinical presentation and various treatment modalities which can be undertaken for Odontogenic Keratocyst.