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in this book you can find the recent importance of the odour molecules. Until now the odorant receptors are greatly underappreciated. Olfaction is very important for the live of humans and animals. However, animals depend more on olfaction than humans. They depend on olfaction in order to distinguish suitable food from unfit foodstuff, to avoid danger, protect themselves from enemies, communicate that way, and find a receptive mate. A lot of these functions have changed throughout the human evolution. Humans do not depend on olfaction to remain alive or to exist because they rely more on the visual and auditory senses now, but nevertheless it is still very important fact in humans life in comparison with other senses. Odorant receptors (ORs) are not only found within the nose, but also in many other organs such as the skin, liver, heart, kidney, lungs, colon, brain and even sperm. ORs play an important role in several physiological functions. Thus, a prediction of the 3D structures of these receptors and docking with different odorant molecules is very important.