Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors

Volume 115
Herausgegeben:Kenakin, Terry P.

• Gebundenes Buch

Produktbeschreibung

In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology.

Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research.

Produktdetails

• Progress in Molecular Biology and Translational Science Volume 115
• Verlag: Academic Press / Elsevier Science & Technology
• Artikelnr. des Verlages: C2011-0-07846-8
• Seitenzahl: 488
• Erscheinungstermin: 28. Februar 2013
• Englisch
• Abmessung: 236mm x 156mm x 30mm
• Gewicht: 893g
• ISBN-13: 9780123945877
• ISBN-10: 0123945879
• Artikelnr.: 36722202

Autorenporträt

Dr. Terry Kenakin is Professor of Pharmacology at the University of North Carolina School of Medicine. Prior to this, he spent 7 years in drug discovery at Burroughs-Wellcome. He then moved to GlaxoSmithKline for 25 years. Dr. Kenakin has written 11 books on Pharmacology, is the Editor in Chief of the Journal of Receptors and Signal Transduction, is on numerous Editorial Boards. He is the Editor-in-Chief of Comprehensive Pharmacology (Elsevier, 2022). He is the recipient of the 2008 Poulsson Medal for Pharmacology awarded by the Norwegian Society of Pharmacology for achievements in basic and clinical pharmacology and toxicology. He has also been awarded the 2011 Ariens Award from the Dutch Pharmacological Society and the 2014 Gaddum Memorial Award from the British Pharmacological Society, and the 2020 Goodman and Gilman Award in Receptor Pharmacology from ASPET.

Inhaltsangabe

1. Approaches for Probing Allosteric Interactions at 7 Transmembrane Spanning Receptors


Michael T. Klein, Paige N. Vinson and Colleen M. Niswender




2. Pharmacology of Metabotropic Glutamate Receptor Allosteric Modulators: Structural Basis and Therapeutic Potential for CNS Disorders


Karen J. Gregory, Meredith J. Noetzel and Colleen M. Niswender




3. Mining the Potential of Label-Free Biosensors for Seven-Transmembrane Receptor Drug Discovery


Magalie Rochville, Julio Martin, Jeffrey Clifford Jerman & Evi Kostenis




4. G Protein-Coupled Receptors in Cancer : Biochemical Interactions and Drug Design


Yves Audigier, François-Xavier Picault, Carline Chaves-Almagro and Bernard Masri




5. GPCRs in Stem Cell Function


Van A. Doze and Dianne M. Perez




6. Application of Receptor Theory to Allosteric Modulation of Receptors


David A. Hall




7. What Ligand-Gated Ion Channels Can Tell Us about the Allosteric Regulation of G protein-Coupled Receptors


Frederick J. Ehlert




8. Modelling Cooperativity Effects in Dimeric G Protein-Coupled Receptors


Jesús Giraldo




9. Chemokine Receptor Oligomerization and Allostery


Bryan Stephens and Tracy M. Handel




10. Fine-Tuning of GPCR Signals by Intracellular G Protein Modulators Peishen Zhao, Wendy Cladman, Hubert HM Van Tol and Peter Chidiac

Rezensionen

Praise for the series: "Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal