Oligomerization in Health and Disease

Volume 117
Herausgegeben:Giraldo, Jesus; Ciruela, Francisco

• Gebundenes Buch

Produktbeschreibung

This special volume of Progress in Molecular Biology and Translational Science focuses on oligomerization in health and disease.

Produktdetails

• Progress in Molecular Biology and Translational Science Volume 117
• Verlag: Academic Press / Elsevier Science & Technology
• Artikelnr. des Verlages: C2010-0-68596-8
• Seitenzahl: 656
• Erscheinungstermin: 30. Mai 2013
• Englisch
• Abmessung: 236mm x 159mm x 38mm
• Gewicht: 1164g
• ISBN-13: 9780123869319
• ISBN-10: 0123869315
• Artikelnr.: 37500564

Inhaltsangabe

Section I. Structural, Physico-Chemical, and Evolutionary Aspects of Protein Oligomerization

1. Evolutionary, Physico-Chemical and Functional Mechanisms of Protein Homooligomerization



2. Structural, Evolutionary and Assembly Principles of Protein Oligomerization



3. Physico-Chemical Principles of Protein Aggregation



4. Structural Aspects of Amyloid Formation


Section II. Oligomerization in Seven-Transmembrane Receptors


5. Quaternary Structure Predictions and Structural Communication Features of GPCR Dimers



6. Challenges in the Development of Heteromer-GPCR-Based Drugs



7. Oligomerization of GPCRs in Health and Disease on "Di/Oligomerisation of GPCRS; Mechanisms and Functional Significance"



8. G Protein-Coupled Receptor Heterocomplexes in Neuropsychiatric Disorders



9. Disease-Specific Heteromerization of G Protein-Coupled Receptors that Target Drugs of Abuse


Section III. Oligomerization in Ion Channels


10. Social Networking among Voltage-Gated Potassium Channels



11. Oligomerization of the Mitochondrial Protein VDAC1: From Structure to Function and Cancer Therapy



12. Consequences of Dimerization of the Voltage Gated Proton Channel



13. Receptor Heteromeric Assembly, How it Works and Why it Matters - The Case of Ionotropic Glutamate Receptors


Section IV. Oligomerization in Enzymes


14. The Structural Basis for the Allosteric Regulation of Ribonucleotide Reductase



15. Oligomerization of Dynamin Superfamily Proteins in Health and Disease



16. Multimerization of the Dnmt3a DNA Methyltransferase and its Functional Implications



17. Oligomerization in Endoplasmic Reticulum Stress Signaling


Section V. Oligomerization in Regulatory Proteins


18. Toll-IL-1-Receptor-Containing Adaptor Molecule-1 (TICAM-1), a Signaling Adaptor Linking Innate Immunity to Adaptive Immunity



19. Assembly of Gamma-Tubulin Ring Complexes: Implications for Cell Biology and Disease



20. Chemokine Oligomerization in Cell Signaling and Migration



21. Oligomerization of Rab/Effector Complexes in the Regulation of Vesicle Trafficking

Rezensionen

Praise for the series: "Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal