THOMAS TUSCHL

Oligonucleotide Therapeutics

First Annual Meetingof the Oligonucleotide Therapeutics Society, Volume 1082
Herausgeber: Tuschl, Thomas; Rossi, John J

• Broschiertes Buch

Produktbeschreibung

This volume concentrates on the most relevant oligonucleotide research and drug development areas and emphasizes the basic mechanisms and biology of oligonucleotide reagents. Chapters are devoted to RNAi, oligonucleotide delivery, and immunomodulation. Because of the advanced stages of oligonucleotide-based drug development, preclinical and clinical data are also presented by leaders in the field. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

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Produktdetails

• Verlag: Wiley
• Seitenzahl: 300
• Erscheinungstermin: 15. Dezember 2006
• Englisch
• Abmessung: 228mm x 153mm x 8mm
• Gewicht: 318g
• ISBN-13: 9781573315876
• ISBN-10: 1573315877
• Artikelnr.: 22728020

Autorenporträt

Thomas Tuschl is a German biochemist and molecular biologist, known for his research on RNA. John J. Rossi is the editor of Oligonucleotide Therapeutics: First Annual Meetingof the Oligonucleotide Therapeutics Society, Volume 1082, published by Wiley.

Inhaltsangabe

I. Delivery:.
1. Targeted Delivery of Antisense Oligonucleotide and Small Interference
RNA into Lung Cancer Cells: Shyh-Dar Li.
2. Atelocollagen-Mediated Systemic DDS for Nucleic Acid Medicines: Koji
Hanai.
3. Intracellular Delivery of Oligonucleotide Conjugates and Dendrimer
Complexes: R.L. Juliano.
4. Mechanism of PNA Transport to the Nuclear Compartment: Lenka Stankova,
Amy J. Ziemba, Zhanna V. Zhilina, and Scot W. Ebbinghaus.
II. Immunomodulation:.
5. The Concept of Immunostimulatory Nucleic Acids: CpG, the Plasmacytoid
Dendritic Cell and Beyond: Gunther Hartmann.
6. Molecular Interaction of Toll-Like Receptor 9 and Nucleic Acid: Eicke
Latz.
7. Effects of CpG ODN on Plasmacytoid Dendritic Cell-Induced Generation of
Regulatory T Cells and Immune Tolerance: Wei Chen.
8. Induction of an Apoptotic Pathway in CLL Cells Stimulated by CpG ODN:
George J. Weiner.
III. Identifying and Validating Targets and Systems:.
9. RNA Silencing in the Struggle Against Disease: Volker Patzel, Isabell
Dietrich & Stefan H. E. Kaufmann.
10. shRNA as antiHIV Therapy: John J. Rossi.
11. Cellular Dynamics of Antisense Oligonucleotides and Short Interfering
RNAs: Li Kim Lee, Brandee M. Dunham, Zhuting Li, and Charles M. Roth.
12. Inhibition of Hepatitis C IRES-mediated Gene Expression by Small
Hairpin RNAs in Human Hepatocytes and Mice: Roger L. Kaspar, Qian Wang,
Attila A. Seyhan, Heini Ilves, Alexander V. Vlassov, Christopher H. Contag,
and Brian H. Johnston.
13. SiRNA-mediated Selective Inhibition of Mutant Keratin mRNAs Responsible
for the Skin Disorder Pachyonychia Congenital: Robyn P. Hickerson, Frances
J. D. Smith, W. H. Irwin McLean, Markus Landthaler, Rudolf Leube and Roger
L. Kaspar.
14. Importance of Pharmacodynamic Studies- Discovering "Real" Mechanisms of
Action: Cy A. Stein.
15. Multi-targeted Approach Using Antisense Oligonucleotides for the
Treatment of Asthma: Z. Allakhverdia, M. Allama, A. Guimondb, N. Ferrari,
K. Zemzoumib,.
R. Séguinb, L. Paquetb and P. M. Renzi.
16. Therapeutic Modulation of DMD Splicing by Blocking Exonic Splicing
Enhancer Sites with Antisense Oligonucleotides: A. Aartsma-Rus, A.A.M.
Janson, J.A. Heemskerk, C.L. de Winter, G-J.B. van Ommen and J.C.T. van
Deutekom.
17. RNA- Targeted Suppression of Acetylcholinesterase: Hermona Soreq and
Amir Dori.
18. Characterization of Antisense Oligonucleotides Comprised of
2'-deoxy-2'-fluoro-D-arabinonucleic Acid: Specificity, Potency and Duration
of Activity: Nicolay Ferrari, Denis Bergeron, Anna-Lisa Tedeschi, Maria M.
Mangos, Luc Paquet, Paolo M. Renzi and Masad J. Damha.
19. Anti-HIV Activity of Steric Block Oligonucleotides: Gabriela Ivanova,
Andrey A. Arzumanov, John J. Turner, Sandrine Reigadas, Jean-Jacques
Toulme, Douglas E. Brown, Andrew M.L. Lever and Michael J. Gait.
20. Selection of Thioaptamers for Diagnostics and Therapeutics: Xianbin
Yang, He Wang, David W. C. Beasley, David E. Volk, Xu Zhao, Bruce A. Luxon,
Lee O. Lomas, Norbert Herzog, Judith F. Aronson, Alan D. T. Barrett, James
F. Leary, and David G. Gorenstein.
21. Small Fragment Homologous Replacement - mediated Modification of The
PIG CFTR GENE: Rosalie Maurisse1, Judy Cheung, Jonathan Widdicombe, Dieter
C. Gruenert.
IV. Clinical Studies:.
22. Neucleic Acids for Treating Leukemia and Lymphoma: Alan M. Gewirtz.
23. Clinical Development of B-and C-Class CpG ODN: In Vivo Modulation of
Plasmacytoid Dendric Cell Function by Regulating ODN Secondary Structure:
Arthur M. Kreig.
24. CpG Oligonucleotides Improve the Protective Immune Response Induced by
the Licensed Anthrax Vaccine: Dennis M. Klinman, Hang Xie, Bruce E. Ivins,.
25. CpG Oligonucleotides Improve the Protective Immune Response Induced by
the Licensed Anthrax Vaccine: Dennis M. Klinman.
26. Anti-VEGF Aptamer (Pegaptanib) Therapy for Ocular Vascular Diseases:
Eugene W. M. Ng and Anthony P. Adamis