Optimization is the most important tool to develop a dosage form. Development of pharmaceuticals especially solid dosage forms can be executed by means of optimization, selecting independent and dependent variables. This book is related to optimizing ofloxacin film coated tablets by considering disintegrant as dependent variable followed by Bio-equivalence (BE) studies of the prepared optimized one with few selected brands of similar formulations available in the Indian market. The book is based on the research project work which can be helpful to the students working on the same domain. Antibiotics are the real need of the today and development of the same can be helpful to the society of a particular territory.