In this book, topics such as Investigating and Modeling the Factors Affecting Thermal Optimization and Dynamic Viscosity of Water Hybrid Nanofluid/Carbon Nanotubes via MOPSO using ANN, Validation and Optimization of Thermophysical Properties of Thermal Conductivity and Viscosity of Nanofluid Engine Oil using Neural Network, Modeling and Multi-Objective Optimization of Thermophysical Properties for Thermal Conductivity and Reynolds number of CuO-Water Nanofluid using Artificial Neural Network, Multi-objective optimization to increase Nusselt number and reduce the friction coefficient of water/carbon nanotubes via NSGA II using Response Surface Methodology, Non-linear Vibration and dynamic response of Nano Composite Conical Tube Conveying Fluid Flow are investigated.