Optogenetics

Tools for Controlling and Monitoring Neuronal Activity Volume 196
Herausgegeben:Knopfel, Thomas; Boyden, Edward S.

• Gebundenes Buch

Produktbeschreibung

Optogenetics is a fast-growing field concerning the invention, and use, of molecules that are genetically expressed in cells, and then either report on cellular physiology in optical form, or enable control of specific pathways in cells when actuated by light. This book reviews the current state, as well as the underlying principles and future directions, of a diversity of optogenetic tools of importance for observing and controlling cellular signaling and physiology.

These tools are already revolutionizing neuroscience, and are starting to have impact on fields ranging from metabolism to development to cardiology. The book contains a dozen chapters written by world experts on these topics, half focusing on the optogenetic molecular tools themselves, and half on the genetic and hardware approaches that make them powerfully useful in intact tissues and organisms.

Produktdetails

• Progress in Brain Research Volume 196
• Verlag: Elsevier Science
• Artikelnr. des Verlages: C2011-0-05056-1
• Seitenzahl: 288
• Erscheinungstermin: 19. April 2012
• Englisch
• Abmessung: 287mm x 217mm x 20mm
• Gewicht: 868g
• ISBN-13: 9780444594266
• ISBN-10: 0444594264
• Artikelnr.: 35469300

Inhaltsangabe

1. A comprehensive concept of optogenetics


Guillaume P. Dugué, Walther Akemann, and Thomas Knöpfel


2. Optogenetic excitation of neurons with channelrhodopsins: light instrumentation, expression systems, and channelrhodopsin variants


John Y. Lin


3. Genetically encoded molecular tools for light-driven silencing of targeted neurons


Brian Y. Chow, Xue Han, and Edward S. Boyden


4. Genetically encoded probes for optical imaging of brain electrical activity


Amelie Perron, Walther Akemann, Hiroki Mutoh and Thomas Knöpfel


5. Neural activity imaging with genetically encoded calcium indicators


Lin Tian, Jasper Akerboom, Eric R. Schreiter, and Loren L. Looger


6. Manipulating cellular processes using optical control of protein-protein interactions


Chandra L. Tucker


7. Two-photon optogenetics


Dan Oron, Eirini Papagiakoumou, F. Anselmi, and Valentina Emiliani


8. Zebrafish as an appealing model for optogenetic studies


Joshua Simmich, Eric Staykov, and Ethan Scott


9. Genetic targeting of specific neuronal cell types in the cerebral cortex


Alan Urban, and Jean Rossier


10. Mouse transgenic approaches in optogenetics


Hongkui Zeng, and Linda Madisen


11. Optogenetics in the nonhuman primate


Xue Han


12. Optogenetic Reporters: Fluorescent Protein-Based Genetically-Encoded Indicators of Signaling and Metabolism in the Brain Mathew Tantama, Yin Pun Hung,and Gary Yellen