Optogenetics

Herausgeber: Appasani, Krishnarao

• Gebundenes Buch

Produktbeschreibung

This book provides applications for the revolutionary technique of optogenetics, which combines genetic and optical methods to observe the function of neurons.

Produktdetails

• Verlag: Cambridge University Press
• Seitenzahl: 506
• Erscheinungstermin: 26. März 2019
• Englisch
• Abmessung: 250mm x 175mm x 32mm
• Gewicht: 1046g
• ISBN-13: 9781107053014
• ISBN-10: 1107053013
• Artikelnr.: 48110064

Inhaltsangabe

List of contributors; Foreword; Preface; List of abbreviations; Part I.
Optogenetics in Model Organisms: 1. Introduction to optogenetics: from
neuronal function to mapping and disease biology; 2. Uncovering key neurons
for manipulation in mammals; 3. From connectome to function: using
optogenetics to shed light on the Caenorhabditis elegans nervous system;
4. From synapse to behaviour: optogenetic tools for investigation of the
Caenorhabditis elegans nervous system; 5. Using optogenetics in vivo to
stimulate regeneration in Xenopus laevis; Part II. Opsin Biology, Tools and
Technology Platform: 6. Sodium and engineered potassium light-driven pumps;
7. Simultaneous electrophysiology and optogenetic stimulation methods; 8.
Role of electrical activity in horizontal axon growth in the developing
cortex: a time-lapse study using optogenetic stimulation; 9. Development of
an optogenetic tool to regulate protein stability in vivo; 10.
Photo-activatable nucleotide cyclases for synthetic photobiology
applications; 11. Bioluminescence activation of light-sensing molecules;
Part III. Optogenetics in Neurobiology, Brain Circuits and Plasticity: 12.
Optogenetics for neurological disorders: what is a path to the clinic?; 13.
Optogenetic control of astroglia; 14. Optogenetics for neurohormones and
neuropeptides: focus on oxytocin; 15. Optogenetic approaches to investigate
brain circuits; 16. Optogenetic mapping of neuronal connections and their
plasticity; Part IV. Optogenetics in Learning, Neuro-psychiatric Diseases
and Behavior: 17. Optogenetics to study reward learning and addiction; 18.
Optogenetics and the dissection of neural circuits underlying depression
and substance-use disorders; 19. Optogenetics research in behavioral
neuroscience: insights into the brain basis of reward learning and
goal-directed behavior; 20. An optogenetic approach to treat epilepsy; 21.
Using optogenetics and stem cells-derived neural engraftment techniques to
restore lost motor function; Part V. Optogenetics in Vision Restoration and
Memory: 22. Optogenetics in treating retinal disease; 23. Optogenetics for
vision recovery: from traditional to designer optogenetic tools; 24. A
promise of vision restoration; 25. Holographic Optical Neural Interfacing
(HONI) with retinal neurons; 26. Strategies for restoring vision by
transducing a channelrhodopsin gene into retinal ganglion cells; 27.
Optogenetic dissection of a top-down prefrontal-to-hippocampus memory
circuit; Part VI. Optogenetics in Sleep, Prosthetics and Epigenetics of
Neurodegenerative Diseases: 28. Optogenetic dissection of sleep-wake
control: evidence for a thalamic control of sleep architecture; 29.
Optogenetics and auditory implants; 30. Optogenetic stimulation for
cochlear prosthetics; 31. The role of amino acids in neurodegenerative and
addictive diseases; 32. Applications of combinations of deep brain
stimulation and optogenetics: ethical considerations: an epilogue.