Despite a recent drop in affluent countries, cancer has remained one of the most lethal diseases since the dawn of time. Oral cancer has become more common as a result of increased use of cigarettes, alcohol, and other carcinogenic items. Increased awareness, early diagnosis, and therapeutic advancements have also resulted in a significant reduction in mortality. The book covers all elements of oral cancer, including etiological factors, pathophysiology, clinical findings, and several ways for early detection, as well as many pharmacological choices for improved management and therapy. Each chapter begins with a detailed discussion and closes with a glance into future approaches and challenges, using an informal writing style that makes the content accessible to a wider audience.The book provides a better understanding of why oral cancer has consistently placed among the top ten causes of cancer-related mortalities globally by examining both internal (genetics) and external (carcinogens, radiation, and smoking) components that cause cancer.