Oral fluid offer a broad perspective on biological processes and the state of many organs. The human body is made up of several different fluids, including blood, urine, and saliva, GCF, Dentinal fluid which include a lot of proteins that may be linked to a number of systemic and oral disorders. These liquids had many clinical uses, in order to assess and keep track of human health. The widespread effects of many diseases, including cancer, cardiovascular, metabolic, and neurological conditions presented clinical professionals with a challenge in providing and enhancing the diagnosis processes and clinical evaluation of these patients.