Hamartomas are non-neoplastic lesions and they can be noted in any part of the body. Hamartomas involving head-neck region are relatively rare. They usually depict the overgrowth of tissue indigenous to the native area. There are also several molecular expressions regulating the pathogenesis of odontogenic hamartomas and often these findings are suggestive of the hamartomatous nature of these lesions. They should be properly differentiated from choristoma, teratoma, benign and malignant lesion.