Oral HIV-associated Kaposi sarcoma
A clinical study from the Ga-Rankuwa area, South Africa
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Kaposi sarcoma (KS) is one of the most common neoplasms diagnosed in HIV-seropositive subjects. Oral involvement is frequent and is associated with a poor prognosis. The aim of this study was to characterize the features of oral HIV-KS in patients from Ga-Rankuwa, South Africa. Twenty of the 37 patients in the study were females and 17 were males. In 21 patients, the initial presentation of HIV-KS was in the mouth. Other than the fact that females presented with larger ( 10mm) oral KS lesions, there were no statistically significant gender differences. Significantly more patients presented wit...
Kaposi sarcoma (KS) is one of the most common neoplasms diagnosed in HIV-seropositive subjects. Oral involvement is frequent and is associated with a poor prognosis. The aim of this study was to characterize the features of oral HIV-KS in patients from Ga-Rankuwa, South Africa. Twenty of the 37 patients in the study were females and 17 were males. In 21 patients, the initial presentation of HIV-KS was in the mouth. Other than the fact that females presented with larger ( 10mm) oral KS lesions, there were no statistically significant gender differences. Significantly more patients presented with multiple oral HIV-KS lesions than with single lesions. Nine patients developed concomitant facial lymphoedema, and these patients had a significantly lower CD4+ T cell count compared to the rest of the group. The average CD4+ T cell count of the patients who died was significantly lower at the time of oral-KS presentation than of those who survived. In Ga-Rankuwa, South Africa where HIV-KSis prevalent, oral KS affects similarly males and females. A low CD4+ T cell count at the time of oral HIV-KS diagnosis and the development of facial lymphoedema portends a poor prognosis.
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