The Oral Cavity Is One Of The Most Complex Microbial Habotats. In The Human Body The Terminology Used To Describe Microorganisms In The Oral Cavity Refers To The Oral Microflora.In The Future, It May Be Feasible To Target Treatment More Specifically To Particular Pathogens Or More Imaginative Approaches Could Be Used To Prevent Dis So, In This Context The Outcome Of The Current Clinical Trial With Bacteriocin-producing Non-acidogenic But Lightly Competitive Strains Of S. Mutans Will Be A Great Relevance.