Oral Wound Healing
Cell Biology and Clinical Management
Herausgegeben von Larjava, Hannu
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Oral Wound Healing
Cell Biology and Clinical Management
Herausgegeben von Larjava, Hannu
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Oral Wound Healing: Cell Biology and Clinical Management brings experts from around the world together to provide an authoritative reference on the processes, principles and clinical management of wound healing in the oral mucosa. Promoting a thorough understanding of current research on the topic, this new resource draws together thinking on the basic biological processes of wound healing in the oral environment, as well as providing more detailed information and discussion on processes such as inflammation, reepithelialization and angiogenesis. Beyond this, the book goes on to examine topics…mehr
Oral Wound Healing: Cell Biology and Clinical Management brings experts from around the world together to provide an authoritative reference on the processes, principles and clinical management of wound healing in the oral mucosa. Promoting a thorough understanding of current research on the topic, this new resource draws together thinking on the basic biological processes of wound healing in the oral environment, as well as providing more detailed information and discussion on processes such as inflammation, reepithelialization and angiogenesis. Beyond this, the book goes on to examine topics pertinent to the effective clinical management of oral wound healing, bringing together chapters on large dento-facial defects, dental implants, periodontal regeneration, and pulp healing. An essential synthesis of current research and clinical applications, Oral Wound Healing will be an indispensable resource for dental specialists, oral and maxillofacial surgeons as well as researchers in oral medicine and biology.
Produktdetails
- Produktdetails
- Verlag: Wiley & Sons
- Artikelnr. des Verlages: 1A813804810
- 1. Auflage
- Seitenzahl: 432
- Erscheinungstermin: 15. Mai 2012
- Englisch
- Abmessung: 255mm x 182mm x 25mm
- Gewicht: 988g
- ISBN-13: 9780813804811
- ISBN-10: 0813804817
- Artikelnr.: 34444149
- Verlag: Wiley & Sons
- Artikelnr. des Verlages: 1A813804810
- 1. Auflage
- Seitenzahl: 432
- Erscheinungstermin: 15. Mai 2012
- Englisch
- Abmessung: 255mm x 182mm x 25mm
- Gewicht: 988g
- ISBN-13: 9780813804811
- ISBN-10: 0813804817
- Artikelnr.: 34444149
Hannu Larjava, DDS, PhD, DipPerio is Professor and Chair of the Division of Periodontics at the University of British Columbia Faculty of Dentistry.
Contributors xiii Preface xvii 1 Oral Wound Healing: An Overview 1 Hannu
Larjava Clotting and inflammation (chapters 2, 3 and 4) 1
Re-epithelialization and granulation tissue formation (chapters 5 and 6) 2
Angiogenesis (chapter 7) 3 Healing of extraction sockets (chapter 8) 4 Flap
design for periodontal wound healing (chapter 9) 4 Regeneration of
periodontal tissues (chapters 10 and 11) 5 Osteointegration and soft tissue
healing around dental implants (chapter 12) 6 The pulp healing process
(chapter 13) 7 Dermal wound healing and burn wounds (chapter 14) 7 Healing
of large dentofacial defects (chapter 15) 8 References 9 2 Hemostasis,
Coagulation and Complications 11 Carol Oakley and Hannu Larjava
Introduction 11 Primary hemostasis 12 Secondary hemostasis and the
coagulation system 13 Tertiary hemostasis 16 Tissue factor 16 Von
willebrand factor 17 Other coagulation factors 17 Cell-centric model of
hemostasis: from initiation to propagation 18 The procoagulant membrane 20
Membrane particles 22 Endothelium and hemostasis 22 Pro- and anticoagulant
functions 22 Platelets 24 Coagulation and wound healing 26 Limitations of
the waterfall cascade model and screening laboratory tests 26 Implications
for laboratory tests 27 Pre-surgical evaluation to prevent bleeding
problems 27 Conclusions 32 References 32 3 Inflammation and Wound Healing
39 Anna Turabelidze and Luisa Ann DiPietro Introduction 39 The innate
immune response in wounds 39 Inflammatory cell infiltration into wounds 40
Inflammatory cell function in wounds 41 Cytokines and chemokines in wounds
44 Inflammation in oral mucosal wounds 47 Inflammation in fetal wounds 48
Role of inflammation in keloids 49 Inflammation and diabetic wounds 49
Conclusions 50 References 50 4 Specialized Pro-resolving Lipid Derived
Fatty Acid Mediators: Wiring the Circuitry of Effector Immune Homeostasis
57 Gabrielle Fredman and Charles N. Serhan Inflammation: the cardinal signs
57 Complete resolution and tissue homeostasis is the ideal outcome of acute
inflammation 58 Lipoxins, resolvins, protectins and maresins: semper
vigilantes of anti-inflammation and pro-resolution 60 Resolution of
inflammation is an actively regulated process in vivo 66 Resolvins and
protectins are protective in experimental models of inflammatory diseases
67 Specialized pro-resolving lipid mediators in oral medicine: restoration
of tissue homeostasis in experimental periodontitis 70 Resolution and wound
healing 72 Anti-inflammation vs. Pro-resolution 72 Clinical implications
and the development of stable analogs 74 Conclusions 74 Acknowledgments 75
References 75 5 Re-epithelialization of Wounds 81 Leeni Koivisto, Lari
Häkkinen and Hannu Larjava Introduction 81 Keratinocytes form a protective
barrier between an organism and its environment 81 Keratinocytes are
activated rapidly to restore the epithelial barrier after wounding 82 Many
different factors contribute to re-epithelialization 84 Final stages of
re-epithelialization 106 Failure to re-epithelialize: chronic wounds 107
Conclusions 107 References 108 6 Granulation Tissue Formation and
Remodeling 125 Lari Häkkinen, Hannu Larjava and Leeni Koivisto Introduction
125 Overview of connective tissue response to wounding 126 Wound healing
stages 129 Origin and identity of wound fibroblasts 129 Granulation tissue
formation 134 Connective tissue remodeling 151 Re-emergence of quiescent
fibroblast phenotype 156 Specific features of oral mucosal wound healing
157 Conclusions 159 Acknowledgments 159 References 159 7 Angiogenesis and
Wound Healing: Basic Discoveries, Clinical Implications and Therapeutic
Opportunities 175 Peter J. Polverini Introduction 175 How blood vessels
develop 175 Early mechanistic insights into the angiogenic response: from
solid tumors to chronic inflammation and wound healing 177 The role of
other inflammatory cells in angiogenesis 179 Matrix molecules 180 Vascular
endothelial growth factor and the modern era of angiogenesis research 181
Signaling networks of potential importance in wound neovascularization 182
Inhibitors of angiogenesis: important counterweights in wound
neovascularization 184 The role of aberrant wound angiogenesis in the
pathogenesis of diabetes mellitus 186 Conclusions 187 References 188 8
Wound Healing of Extraction Sockets 195 Roberto Farina and Leonardo
Trombelli Healing of extraction sockets 195 Factors influencing the healing
of extraction sockets 202 Healing of extraction sockets following immediate
implant placement 203 Does the use of reconstructive technologies alter the
healing of extraction sockets? 211 Conclusions 223 References 223 9 Flap
Designs for Periodontal Healing 229 Leonardo Trombelli and Roberto Farina
Flap management, wound stability and periodontal regeneration 229 Flap
designs to achieve primary closure 230 Surgical treatment of periodontal
intraosseous defects: technical hints 237 Conclusions 240 References 241 10
Periodontal Regeneration: Experimental Observations - Clinical Consequences
243 Ulf M.E. Wikesjö, Cristiano Susin, Jaebum Lee, Douglas P. Dickinson and
Giuseppe Polimeni Introduction 243 Wound healing 244 Periodontal wound
healing 245 Periodontal regeneration - new attachment 247 Wound stability
248 Space provision 251 Wound closure for primary intention healing 256
Conclusions 256 Acknowledgment 257 References 257 11 Biological Agents and
Cell Therapies in Periodontal Regeneration 261 Hannu Larjava, Yi Yang,
Edward Putnins, Jyrki Heino and Lari Häkkinen Introduction 261 Adjunct
growth factors in periodontal wound repair 261 PDGF and IGF-1 in
periodontal regeneration 262 Platelet-rich plasma in periodontal therapy
265 FGF-2 in periodontal regeneration 265 Growth and differentiation
factor-5 in periodontal regeneration 266 Other growth factors in
periodontal regeneration 267 Bioactive collagen-derived peptide in
periodontal regeneration (PepGen P-15(r)) 267 Enamel matrix proteins in
periodontal regeneration and wound healing 269 Stem cells in periodontal
wound healing 273 Conclusions 275 References 275 12 Wound Healing Around
Dental Implants 287 Cristina Cunha Villar, Guy Huynh-Ba, Michael P. Mills
and David L. Cochran Introduction 287 Historical development 287 Titanium -
the metal of choice 290 Healing following implant placement 291
Peri-implant soft tissue healing 291 Implant/peri-implant mucosa interface
292 Peri-implant hard tissue healing 294 From healing to clinical
application 296 Implant stability testing 297 Wound healing and loading
protocols 302 Conclusions 303 References 304 13 The Pulp Healing
Process: From Generation to Regeneration 313 Stéphane Simon, Anthony J.
Smith, Philip J. Lumley, Paul R. Cooper, and Ariane Berdal From generation
to regeneration 313 At the molecular level 323 Conclusion 328 References
328 14 Dermal Wound Healing and Burn Wounds 333 Anthony Papp Introduction
333 Burn injury 333 Skin anatomy 334 Burn depth 336 Wound healing 338
Treatment 340 Special features in perioral burns 342 Conclusions 343
References 344 15 Healing of Large Dentofacial Defects 347 George K.B.
Sándor, Robert P. Carmichael, Leena P. Ylikontiola, Ahmed Jan, Marc G.
DuVal and Cameron M.L. Clokie Introduction 347 The need for bone 349 Bone
healing 349 Surgical maneuvers to induce and promote healing of large
defects 355 Specifically difficult wounds 383 Conclusions 391 References
392 Index 397
Larjava Clotting and inflammation (chapters 2, 3 and 4) 1
Re-epithelialization and granulation tissue formation (chapters 5 and 6) 2
Angiogenesis (chapter 7) 3 Healing of extraction sockets (chapter 8) 4 Flap
design for periodontal wound healing (chapter 9) 4 Regeneration of
periodontal tissues (chapters 10 and 11) 5 Osteointegration and soft tissue
healing around dental implants (chapter 12) 6 The pulp healing process
(chapter 13) 7 Dermal wound healing and burn wounds (chapter 14) 7 Healing
of large dentofacial defects (chapter 15) 8 References 9 2 Hemostasis,
Coagulation and Complications 11 Carol Oakley and Hannu Larjava
Introduction 11 Primary hemostasis 12 Secondary hemostasis and the
coagulation system 13 Tertiary hemostasis 16 Tissue factor 16 Von
willebrand factor 17 Other coagulation factors 17 Cell-centric model of
hemostasis: from initiation to propagation 18 The procoagulant membrane 20
Membrane particles 22 Endothelium and hemostasis 22 Pro- and anticoagulant
functions 22 Platelets 24 Coagulation and wound healing 26 Limitations of
the waterfall cascade model and screening laboratory tests 26 Implications
for laboratory tests 27 Pre-surgical evaluation to prevent bleeding
problems 27 Conclusions 32 References 32 3 Inflammation and Wound Healing
39 Anna Turabelidze and Luisa Ann DiPietro Introduction 39 The innate
immune response in wounds 39 Inflammatory cell infiltration into wounds 40
Inflammatory cell function in wounds 41 Cytokines and chemokines in wounds
44 Inflammation in oral mucosal wounds 47 Inflammation in fetal wounds 48
Role of inflammation in keloids 49 Inflammation and diabetic wounds 49
Conclusions 50 References 50 4 Specialized Pro-resolving Lipid Derived
Fatty Acid Mediators: Wiring the Circuitry of Effector Immune Homeostasis
57 Gabrielle Fredman and Charles N. Serhan Inflammation: the cardinal signs
57 Complete resolution and tissue homeostasis is the ideal outcome of acute
inflammation 58 Lipoxins, resolvins, protectins and maresins: semper
vigilantes of anti-inflammation and pro-resolution 60 Resolution of
inflammation is an actively regulated process in vivo 66 Resolvins and
protectins are protective in experimental models of inflammatory diseases
67 Specialized pro-resolving lipid mediators in oral medicine: restoration
of tissue homeostasis in experimental periodontitis 70 Resolution and wound
healing 72 Anti-inflammation vs. Pro-resolution 72 Clinical implications
and the development of stable analogs 74 Conclusions 74 Acknowledgments 75
References 75 5 Re-epithelialization of Wounds 81 Leeni Koivisto, Lari
Häkkinen and Hannu Larjava Introduction 81 Keratinocytes form a protective
barrier between an organism and its environment 81 Keratinocytes are
activated rapidly to restore the epithelial barrier after wounding 82 Many
different factors contribute to re-epithelialization 84 Final stages of
re-epithelialization 106 Failure to re-epithelialize: chronic wounds 107
Conclusions 107 References 108 6 Granulation Tissue Formation and
Remodeling 125 Lari Häkkinen, Hannu Larjava and Leeni Koivisto Introduction
125 Overview of connective tissue response to wounding 126 Wound healing
stages 129 Origin and identity of wound fibroblasts 129 Granulation tissue
formation 134 Connective tissue remodeling 151 Re-emergence of quiescent
fibroblast phenotype 156 Specific features of oral mucosal wound healing
157 Conclusions 159 Acknowledgments 159 References 159 7 Angiogenesis and
Wound Healing: Basic Discoveries, Clinical Implications and Therapeutic
Opportunities 175 Peter J. Polverini Introduction 175 How blood vessels
develop 175 Early mechanistic insights into the angiogenic response: from
solid tumors to chronic inflammation and wound healing 177 The role of
other inflammatory cells in angiogenesis 179 Matrix molecules 180 Vascular
endothelial growth factor and the modern era of angiogenesis research 181
Signaling networks of potential importance in wound neovascularization 182
Inhibitors of angiogenesis: important counterweights in wound
neovascularization 184 The role of aberrant wound angiogenesis in the
pathogenesis of diabetes mellitus 186 Conclusions 187 References 188 8
Wound Healing of Extraction Sockets 195 Roberto Farina and Leonardo
Trombelli Healing of extraction sockets 195 Factors influencing the healing
of extraction sockets 202 Healing of extraction sockets following immediate
implant placement 203 Does the use of reconstructive technologies alter the
healing of extraction sockets? 211 Conclusions 223 References 223 9 Flap
Designs for Periodontal Healing 229 Leonardo Trombelli and Roberto Farina
Flap management, wound stability and periodontal regeneration 229 Flap
designs to achieve primary closure 230 Surgical treatment of periodontal
intraosseous defects: technical hints 237 Conclusions 240 References 241 10
Periodontal Regeneration: Experimental Observations - Clinical Consequences
243 Ulf M.E. Wikesjö, Cristiano Susin, Jaebum Lee, Douglas P. Dickinson and
Giuseppe Polimeni Introduction 243 Wound healing 244 Periodontal wound
healing 245 Periodontal regeneration - new attachment 247 Wound stability
248 Space provision 251 Wound closure for primary intention healing 256
Conclusions 256 Acknowledgment 257 References 257 11 Biological Agents and
Cell Therapies in Periodontal Regeneration 261 Hannu Larjava, Yi Yang,
Edward Putnins, Jyrki Heino and Lari Häkkinen Introduction 261 Adjunct
growth factors in periodontal wound repair 261 PDGF and IGF-1 in
periodontal regeneration 262 Platelet-rich plasma in periodontal therapy
265 FGF-2 in periodontal regeneration 265 Growth and differentiation
factor-5 in periodontal regeneration 266 Other growth factors in
periodontal regeneration 267 Bioactive collagen-derived peptide in
periodontal regeneration (PepGen P-15(r)) 267 Enamel matrix proteins in
periodontal regeneration and wound healing 269 Stem cells in periodontal
wound healing 273 Conclusions 275 References 275 12 Wound Healing Around
Dental Implants 287 Cristina Cunha Villar, Guy Huynh-Ba, Michael P. Mills
and David L. Cochran Introduction 287 Historical development 287 Titanium -
the metal of choice 290 Healing following implant placement 291
Peri-implant soft tissue healing 291 Implant/peri-implant mucosa interface
292 Peri-implant hard tissue healing 294 From healing to clinical
application 296 Implant stability testing 297 Wound healing and loading
protocols 302 Conclusions 303 References 304 13 The Pulp Healing
Process: From Generation to Regeneration 313 Stéphane Simon, Anthony J.
Smith, Philip J. Lumley, Paul R. Cooper, and Ariane Berdal From generation
to regeneration 313 At the molecular level 323 Conclusion 328 References
328 14 Dermal Wound Healing and Burn Wounds 333 Anthony Papp Introduction
333 Burn injury 333 Skin anatomy 334 Burn depth 336 Wound healing 338
Treatment 340 Special features in perioral burns 342 Conclusions 343
References 344 15 Healing of Large Dentofacial Defects 347 George K.B.
Sándor, Robert P. Carmichael, Leena P. Ylikontiola, Ahmed Jan, Marc G.
DuVal and Cameron M.L. Clokie Introduction 347 The need for bone 349 Bone
healing 349 Surgical maneuvers to induce and promote healing of large
defects 355 Specifically difficult wounds 383 Conclusions 391 References
392 Index 397
Contributors xiii Preface xvii 1 Oral Wound Healing: An Overview 1 Hannu
Larjava Clotting and inflammation (chapters 2, 3 and 4) 1
Re-epithelialization and granulation tissue formation (chapters 5 and 6) 2
Angiogenesis (chapter 7) 3 Healing of extraction sockets (chapter 8) 4 Flap
design for periodontal wound healing (chapter 9) 4 Regeneration of
periodontal tissues (chapters 10 and 11) 5 Osteointegration and soft tissue
healing around dental implants (chapter 12) 6 The pulp healing process
(chapter 13) 7 Dermal wound healing and burn wounds (chapter 14) 7 Healing
of large dentofacial defects (chapter 15) 8 References 9 2 Hemostasis,
Coagulation and Complications 11 Carol Oakley and Hannu Larjava
Introduction 11 Primary hemostasis 12 Secondary hemostasis and the
coagulation system 13 Tertiary hemostasis 16 Tissue factor 16 Von
willebrand factor 17 Other coagulation factors 17 Cell-centric model of
hemostasis: from initiation to propagation 18 The procoagulant membrane 20
Membrane particles 22 Endothelium and hemostasis 22 Pro- and anticoagulant
functions 22 Platelets 24 Coagulation and wound healing 26 Limitations of
the waterfall cascade model and screening laboratory tests 26 Implications
for laboratory tests 27 Pre-surgical evaluation to prevent bleeding
problems 27 Conclusions 32 References 32 3 Inflammation and Wound Healing
39 Anna Turabelidze and Luisa Ann DiPietro Introduction 39 The innate
immune response in wounds 39 Inflammatory cell infiltration into wounds 40
Inflammatory cell function in wounds 41 Cytokines and chemokines in wounds
44 Inflammation in oral mucosal wounds 47 Inflammation in fetal wounds 48
Role of inflammation in keloids 49 Inflammation and diabetic wounds 49
Conclusions 50 References 50 4 Specialized Pro-resolving Lipid Derived
Fatty Acid Mediators: Wiring the Circuitry of Effector Immune Homeostasis
57 Gabrielle Fredman and Charles N. Serhan Inflammation: the cardinal signs
57 Complete resolution and tissue homeostasis is the ideal outcome of acute
inflammation 58 Lipoxins, resolvins, protectins and maresins: semper
vigilantes of anti-inflammation and pro-resolution 60 Resolution of
inflammation is an actively regulated process in vivo 66 Resolvins and
protectins are protective in experimental models of inflammatory diseases
67 Specialized pro-resolving lipid mediators in oral medicine: restoration
of tissue homeostasis in experimental periodontitis 70 Resolution and wound
healing 72 Anti-inflammation vs. Pro-resolution 72 Clinical implications
and the development of stable analogs 74 Conclusions 74 Acknowledgments 75
References 75 5 Re-epithelialization of Wounds 81 Leeni Koivisto, Lari
Häkkinen and Hannu Larjava Introduction 81 Keratinocytes form a protective
barrier between an organism and its environment 81 Keratinocytes are
activated rapidly to restore the epithelial barrier after wounding 82 Many
different factors contribute to re-epithelialization 84 Final stages of
re-epithelialization 106 Failure to re-epithelialize: chronic wounds 107
Conclusions 107 References 108 6 Granulation Tissue Formation and
Remodeling 125 Lari Häkkinen, Hannu Larjava and Leeni Koivisto Introduction
125 Overview of connective tissue response to wounding 126 Wound healing
stages 129 Origin and identity of wound fibroblasts 129 Granulation tissue
formation 134 Connective tissue remodeling 151 Re-emergence of quiescent
fibroblast phenotype 156 Specific features of oral mucosal wound healing
157 Conclusions 159 Acknowledgments 159 References 159 7 Angiogenesis and
Wound Healing: Basic Discoveries, Clinical Implications and Therapeutic
Opportunities 175 Peter J. Polverini Introduction 175 How blood vessels
develop 175 Early mechanistic insights into the angiogenic response: from
solid tumors to chronic inflammation and wound healing 177 The role of
other inflammatory cells in angiogenesis 179 Matrix molecules 180 Vascular
endothelial growth factor and the modern era of angiogenesis research 181
Signaling networks of potential importance in wound neovascularization 182
Inhibitors of angiogenesis: important counterweights in wound
neovascularization 184 The role of aberrant wound angiogenesis in the
pathogenesis of diabetes mellitus 186 Conclusions 187 References 188 8
Wound Healing of Extraction Sockets 195 Roberto Farina and Leonardo
Trombelli Healing of extraction sockets 195 Factors influencing the healing
of extraction sockets 202 Healing of extraction sockets following immediate
implant placement 203 Does the use of reconstructive technologies alter the
healing of extraction sockets? 211 Conclusions 223 References 223 9 Flap
Designs for Periodontal Healing 229 Leonardo Trombelli and Roberto Farina
Flap management, wound stability and periodontal regeneration 229 Flap
designs to achieve primary closure 230 Surgical treatment of periodontal
intraosseous defects: technical hints 237 Conclusions 240 References 241 10
Periodontal Regeneration: Experimental Observations - Clinical Consequences
243 Ulf M.E. Wikesjö, Cristiano Susin, Jaebum Lee, Douglas P. Dickinson and
Giuseppe Polimeni Introduction 243 Wound healing 244 Periodontal wound
healing 245 Periodontal regeneration - new attachment 247 Wound stability
248 Space provision 251 Wound closure for primary intention healing 256
Conclusions 256 Acknowledgment 257 References 257 11 Biological Agents and
Cell Therapies in Periodontal Regeneration 261 Hannu Larjava, Yi Yang,
Edward Putnins, Jyrki Heino and Lari Häkkinen Introduction 261 Adjunct
growth factors in periodontal wound repair 261 PDGF and IGF-1 in
periodontal regeneration 262 Platelet-rich plasma in periodontal therapy
265 FGF-2 in periodontal regeneration 265 Growth and differentiation
factor-5 in periodontal regeneration 266 Other growth factors in
periodontal regeneration 267 Bioactive collagen-derived peptide in
periodontal regeneration (PepGen P-15(r)) 267 Enamel matrix proteins in
periodontal regeneration and wound healing 269 Stem cells in periodontal
wound healing 273 Conclusions 275 References 275 12 Wound Healing Around
Dental Implants 287 Cristina Cunha Villar, Guy Huynh-Ba, Michael P. Mills
and David L. Cochran Introduction 287 Historical development 287 Titanium -
the metal of choice 290 Healing following implant placement 291
Peri-implant soft tissue healing 291 Implant/peri-implant mucosa interface
292 Peri-implant hard tissue healing 294 From healing to clinical
application 296 Implant stability testing 297 Wound healing and loading
protocols 302 Conclusions 303 References 304 13 The Pulp Healing
Process: From Generation to Regeneration 313 Stéphane Simon, Anthony J.
Smith, Philip J. Lumley, Paul R. Cooper, and Ariane Berdal From generation
to regeneration 313 At the molecular level 323 Conclusion 328 References
328 14 Dermal Wound Healing and Burn Wounds 333 Anthony Papp Introduction
333 Burn injury 333 Skin anatomy 334 Burn depth 336 Wound healing 338
Treatment 340 Special features in perioral burns 342 Conclusions 343
References 344 15 Healing of Large Dentofacial Defects 347 George K.B.
Sándor, Robert P. Carmichael, Leena P. Ylikontiola, Ahmed Jan, Marc G.
DuVal and Cameron M.L. Clokie Introduction 347 The need for bone 349 Bone
healing 349 Surgical maneuvers to induce and promote healing of large
defects 355 Specifically difficult wounds 383 Conclusions 391 References
392 Index 397
Larjava Clotting and inflammation (chapters 2, 3 and 4) 1
Re-epithelialization and granulation tissue formation (chapters 5 and 6) 2
Angiogenesis (chapter 7) 3 Healing of extraction sockets (chapter 8) 4 Flap
design for periodontal wound healing (chapter 9) 4 Regeneration of
periodontal tissues (chapters 10 and 11) 5 Osteointegration and soft tissue
healing around dental implants (chapter 12) 6 The pulp healing process
(chapter 13) 7 Dermal wound healing and burn wounds (chapter 14) 7 Healing
of large dentofacial defects (chapter 15) 8 References 9 2 Hemostasis,
Coagulation and Complications 11 Carol Oakley and Hannu Larjava
Introduction 11 Primary hemostasis 12 Secondary hemostasis and the
coagulation system 13 Tertiary hemostasis 16 Tissue factor 16 Von
willebrand factor 17 Other coagulation factors 17 Cell-centric model of
hemostasis: from initiation to propagation 18 The procoagulant membrane 20
Membrane particles 22 Endothelium and hemostasis 22 Pro- and anticoagulant
functions 22 Platelets 24 Coagulation and wound healing 26 Limitations of
the waterfall cascade model and screening laboratory tests 26 Implications
for laboratory tests 27 Pre-surgical evaluation to prevent bleeding
problems 27 Conclusions 32 References 32 3 Inflammation and Wound Healing
39 Anna Turabelidze and Luisa Ann DiPietro Introduction 39 The innate
immune response in wounds 39 Inflammatory cell infiltration into wounds 40
Inflammatory cell function in wounds 41 Cytokines and chemokines in wounds
44 Inflammation in oral mucosal wounds 47 Inflammation in fetal wounds 48
Role of inflammation in keloids 49 Inflammation and diabetic wounds 49
Conclusions 50 References 50 4 Specialized Pro-resolving Lipid Derived
Fatty Acid Mediators: Wiring the Circuitry of Effector Immune Homeostasis
57 Gabrielle Fredman and Charles N. Serhan Inflammation: the cardinal signs
57 Complete resolution and tissue homeostasis is the ideal outcome of acute
inflammation 58 Lipoxins, resolvins, protectins and maresins: semper
vigilantes of anti-inflammation and pro-resolution 60 Resolution of
inflammation is an actively regulated process in vivo 66 Resolvins and
protectins are protective in experimental models of inflammatory diseases
67 Specialized pro-resolving lipid mediators in oral medicine: restoration
of tissue homeostasis in experimental periodontitis 70 Resolution and wound
healing 72 Anti-inflammation vs. Pro-resolution 72 Clinical implications
and the development of stable analogs 74 Conclusions 74 Acknowledgments 75
References 75 5 Re-epithelialization of Wounds 81 Leeni Koivisto, Lari
Häkkinen and Hannu Larjava Introduction 81 Keratinocytes form a protective
barrier between an organism and its environment 81 Keratinocytes are
activated rapidly to restore the epithelial barrier after wounding 82 Many
different factors contribute to re-epithelialization 84 Final stages of
re-epithelialization 106 Failure to re-epithelialize: chronic wounds 107
Conclusions 107 References 108 6 Granulation Tissue Formation and
Remodeling 125 Lari Häkkinen, Hannu Larjava and Leeni Koivisto Introduction
125 Overview of connective tissue response to wounding 126 Wound healing
stages 129 Origin and identity of wound fibroblasts 129 Granulation tissue
formation 134 Connective tissue remodeling 151 Re-emergence of quiescent
fibroblast phenotype 156 Specific features of oral mucosal wound healing
157 Conclusions 159 Acknowledgments 159 References 159 7 Angiogenesis and
Wound Healing: Basic Discoveries, Clinical Implications and Therapeutic
Opportunities 175 Peter J. Polverini Introduction 175 How blood vessels
develop 175 Early mechanistic insights into the angiogenic response: from
solid tumors to chronic inflammation and wound healing 177 The role of
other inflammatory cells in angiogenesis 179 Matrix molecules 180 Vascular
endothelial growth factor and the modern era of angiogenesis research 181
Signaling networks of potential importance in wound neovascularization 182
Inhibitors of angiogenesis: important counterweights in wound
neovascularization 184 The role of aberrant wound angiogenesis in the
pathogenesis of diabetes mellitus 186 Conclusions 187 References 188 8
Wound Healing of Extraction Sockets 195 Roberto Farina and Leonardo
Trombelli Healing of extraction sockets 195 Factors influencing the healing
of extraction sockets 202 Healing of extraction sockets following immediate
implant placement 203 Does the use of reconstructive technologies alter the
healing of extraction sockets? 211 Conclusions 223 References 223 9 Flap
Designs for Periodontal Healing 229 Leonardo Trombelli and Roberto Farina
Flap management, wound stability and periodontal regeneration 229 Flap
designs to achieve primary closure 230 Surgical treatment of periodontal
intraosseous defects: technical hints 237 Conclusions 240 References 241 10
Periodontal Regeneration: Experimental Observations - Clinical Consequences
243 Ulf M.E. Wikesjö, Cristiano Susin, Jaebum Lee, Douglas P. Dickinson and
Giuseppe Polimeni Introduction 243 Wound healing 244 Periodontal wound
healing 245 Periodontal regeneration - new attachment 247 Wound stability
248 Space provision 251 Wound closure for primary intention healing 256
Conclusions 256 Acknowledgment 257 References 257 11 Biological Agents and
Cell Therapies in Periodontal Regeneration 261 Hannu Larjava, Yi Yang,
Edward Putnins, Jyrki Heino and Lari Häkkinen Introduction 261 Adjunct
growth factors in periodontal wound repair 261 PDGF and IGF-1 in
periodontal regeneration 262 Platelet-rich plasma in periodontal therapy
265 FGF-2 in periodontal regeneration 265 Growth and differentiation
factor-5 in periodontal regeneration 266 Other growth factors in
periodontal regeneration 267 Bioactive collagen-derived peptide in
periodontal regeneration (PepGen P-15(r)) 267 Enamel matrix proteins in
periodontal regeneration and wound healing 269 Stem cells in periodontal
wound healing 273 Conclusions 275 References 275 12 Wound Healing Around
Dental Implants 287 Cristina Cunha Villar, Guy Huynh-Ba, Michael P. Mills
and David L. Cochran Introduction 287 Historical development 287 Titanium -
the metal of choice 290 Healing following implant placement 291
Peri-implant soft tissue healing 291 Implant/peri-implant mucosa interface
292 Peri-implant hard tissue healing 294 From healing to clinical
application 296 Implant stability testing 297 Wound healing and loading
protocols 302 Conclusions 303 References 304 13 The Pulp Healing
Process: From Generation to Regeneration 313 Stéphane Simon, Anthony J.
Smith, Philip J. Lumley, Paul R. Cooper, and Ariane Berdal From generation
to regeneration 313 At the molecular level 323 Conclusion 328 References
328 14 Dermal Wound Healing and Burn Wounds 333 Anthony Papp Introduction
333 Burn injury 333 Skin anatomy 334 Burn depth 336 Wound healing 338
Treatment 340 Special features in perioral burns 342 Conclusions 343
References 344 15 Healing of Large Dentofacial Defects 347 George K.B.
Sándor, Robert P. Carmichael, Leena P. Ylikontiola, Ahmed Jan, Marc G.
DuVal and Cameron M.L. Clokie Introduction 347 The need for bone 349 Bone
healing 349 Surgical maneuvers to induce and promote healing of large
defects 355 Specifically difficult wounds 383 Conclusions 391 References
392 Index 397