This comprehensive guide aims to equip farmers, agricultural extension workers, policymakers, and researchers with the knowledge and tools necessary to maximize the benefits of OFSP production and contribute to food security and economic development in Nigeria. The Comprehensive Guide also aims to be an all-encompassing resource for various stakeholders involved in the cultivation, management, and commercialization of orange-fleshed sweet potatoes (OFSP) in Nigeria. This guide will provide for households and commercial farmers hands-on knowledge on OFSP planting at home or on farm. It is easy to comprehend by anyone willing to plant OFSP at any time of the year and anywhere in the Nigeria. Household meal planners and rural processors can easily access information on the value addition, processing, and utilization of Orange-Fleshed Sweet Potatoes (OFSP) to enhance food and nutrition security, ultimately boosting their livelihoods.