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This Special Issue aims to explore fresh scholarship on the debates regarding organ transplantation and organ and tissue donation in Islam-not only describing the prevailing judgments made by Muslim scholars and jurists on the subject matter but also, and perhaps even more importantly, critiquing them by putting their ontological and epistemological methodologies, theological rationales, and legal and jurisprudential principles under scrutiny. To this end, scholars and researchers are invited to examine organ transplantation and organ and tissue donation in Islam from their respective areas of expertise and disciplinary fields.