Volkmar Weissig, Gerard G. D'Souza

Organelle-Specific Pharmaceutical Nanotechnology

• Gebundenes Buch

Produktbeschreibung

This book introduces and discusses the latest in biomedical research--Pharmaceutical Nanotechnology applied at the sub-cellular level.

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Produktdetails

• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 608
• Erscheinungstermin: 2. November 2010
• Englisch
• Abmessung: 236mm x 160mm x 38mm
• Gewicht: 1089g
• ISBN-13: 9780470631652
• ISBN-10: 0470631651
• Artikelnr.: 30628303

Autorenporträt

Volkmar Weissig, ScD, PhD, is Associate Professor of Pharmacology at Midwestern University in Glendale, Arizona. He has been actively pioneering mitochondrial pharmaceutics for the last decade. The holder of sixteen patents and author of more than eighty research papers, review articles, and book chapters, Dr. Weissig serves as Associate Editor of the Journal of Liposome Research and is the member of several other editorial boards. He is an active member of the International Liposome Society, the Mitochondria Research Society, the American Association of Pharmaceutical Scientists, and the American Association for the Advancement of Science. Gerard G.M. D'Souza, PhD, is Assistant Professor of Pharmaceutics at Massachusetts College of Pharmacy and Health Sciences in Boston. He has coauthored more than twenty peer-reviewed publications in the fields of pharmaceutical nanotechnology and mitochondrial pharmaceutics. Dr. D'Souza is a member of the editorial board for the Journal Drug Delivery and serves as a peer reviewer for several journals in the field of drug delivery.

Inhaltsangabe

Preface.
Contributors.
1. An Introduction to Subcellular Nanomedicine: Current Trends and Future
Developments (Gerard G. M. D'Souza and Volkmar Weissig).
2. Delivery of Nanonsensors to Measure the Intracellular Environment (Paul
G. Coupland and Jonathan W. Aylott).
3. Cytoplasmic Diffi usion of Dendrimers and Dendriplexes (Alexander T.
Florence and Pakatip Ruenraroengsak).
4. Endocytosis and Intracellular Trafficking of Quantum Dot-Ligand
Bioconjugates (Tore-Geir Iversen, Nadine Frerker, and Kirsten Sandvig).
5. Synthesis of Metal Nanoparticle-Based Intracellular Biosensors and
Therapeutic Agents (Neil Bricklebank).
6. Subcellular Fate of Nanodelivery Systems (Dusica Maysinger, Sebastien
Boridy, and Eliza Hutter).
7. Intracellular Fate of Plasmid DNA Polyplexes (Kevin Maier and Ernst
Wagner).
8. Intracellular Trafficking of Membrane Receptor-Mediated Uptake of Carbon
Nanotubes (Bin Kang and Yaodong Dai).
9. Real-Time Particle Tracking for Studying Intracellular Transport of
Nanotherapeutics (Clive Chen and Junghae Suh).
10. Tracking Intracellular Polymer Localization Via Fluorescence Microscopy
(Simon C. W. Richardson).
11. Can QSAR Models Describing Small-Molecule Xenobiotics Give Useful Tips
for Predicting Uptake and Localization of Nanoparticles in Living Cells?
And If Not, Why Not? (Richard W. Horobin).
12. Self-Unpacking Gene Delivery Scaffolds (Millicent O. Sullivan).
13. Cellular Trafficking of Dendrimers (Yunus Emre Kurtoglu and
Rangaramanujam M. Kannan).
14. Endolysosomolytically Active pH-Sensitive Polymeric Nanotechnology (
Han Chang Kang and You Han Bae).
15. Uptake and Intracellular Dynamics of Proteins Internalized by
Cell-Penetrating Peptides (Arwyn T. Jones).
16. Cargo Transport by Teams of Molecular Motors: Basic Mechanisms for
Intracellular Drug Delivery (Melanie J. I. Müller, Florian Berger, Stegan
Klumpp, and Reinhard Lipowsky).
17. The Potential of Photochemical Internalization (PCI) for the Cytosolic
Delivery of Nanomedicines (Kristian Berg, Anette Weyergang, Anders Høgset,
and Pål Kristian Selbo).
18. Peptide-Based Nanocarriers for Intracellular Delivery of Biologically
Active Proteins (Seong Loong Lo and Shu Wang).
19. Organelle-Specific Pharmaceutical Nanotechnology: Active Cellular
Transport of Submicro- and Nanoscale Particles (Galya Orr).
20. Subcellular Targeting of Virus-Envelope-Coated Nanoparticles (Jia Wang,
Mohammad F. Saeed, Andrey A. Kolokoltsov, and Robert A. Davey).
21. Mitochondria-Targeted Pharmaceutical Nanocarriers (Volkmar Weissig and
Gerard G.M. D'Souza).
22. Cell-Penetrating Peptides for Cytosolic Delivery of Biomacromolecules (
Camilla Foged, Xiaona Jing, and Hanne Moerck Nielsen).
23. Therapeutic Nano-object Delivery to Subdomains of Cardiac Myocytes (
Valeriy Lukyanenko).
24. Design Parameters Modulating Intracellular Drug Delivery: Anchoring to
Specific Cellular Epitopes, Carrier Geometry, and Use of Auxiliary
Pharmacological Agents (Silvia Muro and Vladimir R. Muzykantov).
25. Uptake Pathways Dependent Intracellular Trafficking of DNA Carrying
Nanodelivery Systems (Ikramy A. Khalil, Yuma Yamada, Hidetaka Akita, and
Hideyoshi Harashima).
26. Cellular Interactions of Plasmon-Resonant Gold Nanorods (Qingshan Wei
and Alexander Wei).
27. Quantum Dot Labeling for Assessment of Intracellular Trafficking of
Therapeutically Active Molecules (Diane J. Burgess and Mamta Kapoor).
Index.