Reflecting the increased pace of research and the many recent advances in organic chemistry, the Organic Syntheses series serves as a single source compendium of the most up-to-date procedures in use. Organic Syntheses consists of protocols for the synthesis of useful chemical compounds. For each protocol, safety warnings are presented along with detailed experimental descriptions for the preparation, purification, and identification of the compound. Additionally, special reaction conditions are detailed, along with the source of reagents, waste disposal information, a discussion of the…mehr
Reflecting the increased pace of research and the many recent advances in organic chemistry, the Organic Syntheses series serves as a single source compendium of the most up-to-date procedures in use. Organic Syntheses consists of protocols for the synthesis of useful chemical compounds. For each protocol, safety warnings are presented along with detailed experimental descriptions for the preparation, purification, and identification of the compound. Additionally, special reaction conditions are detailed, along with the source of reagents, waste disposal information, a discussion of the results, references to the primary literature, and an appendix of nomenclature and registry numbers.
A 36-year veteran of the Merck Research Laboratories, Edward J. J. Grabowski serves as Executive Director of Process Chemistry. He is a member of the Organic Synthesis Editorial Board and has served on the ACS Petroleum Research Fund's Advisory Board. He is a co-author of approximately 80 research papers and reviews, and a co-inventor on more than 40 U.S. patents.
Preparation of Optically Active (R,R)-Hydrobenzoin From Benxoinor Benzil.
2,2-Diethoxy-1-Isoxyanoethane.
Preparation of (S,S) -1,2--BIS(tert-Butylmethylphosphino)-Ethane((S,S)-t-Bu-BISP) As a Rhodium Complex.
Preparation of Hexakis(4-Bromophenyl)Benzene (HBB).
An Efficient, Highly Diastereo- And EnantioselectiveHetero-Diels-Alder Catalyst. Preparation of (2S,6R)-6-(tert-Butyldimethylsilyloxymethyl)-2-Methoxy-2,5-Diyhdropyran.
Lipase-Catalyzed Resolution of 4-Trimethylsilyl-3-Butyn-2-OL andConversion of the (R)-Enantiomer To (R)-3-Butyn-2-Yl Mesylate and({)-1-tributylstannyl-1,2-Butadiene.
Iridium-Catalyzed Synthesis of Vinyl Ethers from Alcohols andVinyl Acetate.
Ortho-Formylation of Phenols: Preparation of3-Bromosalicylaldehyde.
Preparation of 1-Methoxy-2-(4-Methoxyphenoxy)Benzene.
D-Ribonolactone and 2,3-Isopropylidene-(D-Ribonolactone)
Preparation of4-Acetylamino-2,2,6,6-Tetramethyl-Piperidine-1-OxoammoniumTetrafluoroborate, and the Oxidation of Geraniol to Geranial.
(2S)-(-)-3exo-(Morpholino)Isoborneol [(-)-MIB].
Conversion of Arylalkylketones Into Dichloroalkenes:1-Chloro-4-(2,2-Dichloro-1-Methylvinyl)Benzene.
1,4,-Dioxene.
(R)-(+)-3,4-Dimethylcyclohex-2-EN-1-One.
A Practical and Safe Preparation of3,5-BIS-(Trifluoromethyl)Acetophenone.
Asymmetric Alcoholysis of Meso-Anhydrides Mediated ByAlkaloids.
Iridium-Catalyzed C-HBorylation of Arenes and Heteroarenes:1-Chloro-3-Iodo-5-(4,4,5,5-Tetramethyl-1,3,2,-Dioxaborolan-2-YL)Benzeneand 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-YL)Indole.
Asymmetric Rearrangement of Allylic Trichloroacetimidates:Preparation of (s)-2,2,2-Trichloro-N-(1-Propylallyl)Acetamide.
Preparation of (Triphenylphosphoranylidene)-Ketene From(Methoxycarbonylmethylene)-Triphenylphosphorane.
Preparation of [1-(Methoxymethylcarbamoyl)-Aethyl]PhosphonicAcid BIS(2,2,2-Trifluoroethyl)Ester: A Useful Intermediate in theSynthesis of Z-Unsaturated N-Methoxy-N-Methylamides.
(Rs)-(+)-2-Methyl-2-Propanesulfinamide.
Preparation of 1-Butyl-3-MethylimidazoliumTetrafluoroborate.
Preparation of Optically Active (R,R)-Hydrobenzoin From Benxoinor Benzil.
2,2-Diethoxy-1-Isoxyanoethane.
Preparation of (S,S) -1,2--BIS(tert-Butylmethylphosphino)-Ethane((S,S)-t-Bu-BISP) As a Rhodium Complex.
Preparation of Hexakis(4-Bromophenyl)Benzene (HBB).
An Efficient, Highly Diastereo- And EnantioselectiveHetero-Diels-Alder Catalyst. Preparation of (2S,6R)-6-(tert-Butyldimethylsilyloxymethyl)-2-Methoxy-2,5-Diyhdropyran.
Lipase-Catalyzed Resolution of 4-Trimethylsilyl-3-Butyn-2-OL andConversion of the (R)-Enantiomer To (R)-3-Butyn-2-Yl Mesylate and({)-1-tributylstannyl-1,2-Butadiene.
Iridium-Catalyzed Synthesis of Vinyl Ethers from Alcohols andVinyl Acetate.
Ortho-Formylation of Phenols: Preparation of3-Bromosalicylaldehyde.
Preparation of 1-Methoxy-2-(4-Methoxyphenoxy)Benzene.
D-Ribonolactone and 2,3-Isopropylidene-(D-Ribonolactone)
Preparation of4-Acetylamino-2,2,6,6-Tetramethyl-Piperidine-1-OxoammoniumTetrafluoroborate, and the Oxidation of Geraniol to Geranial.
(2S)-(-)-3exo-(Morpholino)Isoborneol [(-)-MIB].
Conversion of Arylalkylketones Into Dichloroalkenes:1-Chloro-4-(2,2-Dichloro-1-Methylvinyl)Benzene.
1,4,-Dioxene.
(R)-(+)-3,4-Dimethylcyclohex-2-EN-1-One.
A Practical and Safe Preparation of3,5-BIS-(Trifluoromethyl)Acetophenone.
Asymmetric Alcoholysis of Meso-Anhydrides Mediated ByAlkaloids.
Iridium-Catalyzed C-HBorylation of Arenes and Heteroarenes:1-Chloro-3-Iodo-5-(4,4,5,5-Tetramethyl-1,3,2,-Dioxaborolan-2-YL)Benzeneand 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-YL)Indole.
Asymmetric Rearrangement of Allylic Trichloroacetimidates:Preparation of (s)-2,2,2-Trichloro-N-(1-Propylallyl)Acetamide.
Preparation of (Triphenylphosphoranylidene)-Ketene From(Methoxycarbonylmethylene)-Triphenylphosphorane.
Preparation of [1-(Methoxymethylcarbamoyl)-Aethyl]PhosphonicAcid BIS(2,2,2-Trifluoroethyl)Ester: A Useful Intermediate in theSynthesis of Z-Unsaturated N-Methoxy-N-Methylamides.
(Rs)-(+)-2-Methyl-2-Propanesulfinamide.
Preparation of 1-Butyl-3-MethylimidazoliumTetrafluoroborate.
