Organic Syntheses, Volume 87

Herausgeber: Ellman, Jonathan A

• Gebundenes Buch

Produktbeschreibung

Organic syntheses consists of protocols for the synthesis of useful chemical compounds. "Organic Syntheses, Volume 87" provides carefully checked and edited experimental protocols that describe important synthetic methods, transformations, reagents, and synthetic building blocks or intermediates with demonstrated utility in organic synthesis. For each protocol, safety warnings are presented along with detailed experimental descriptions for the preparation, purification, and identification of the compound. Additionally, special reaction conditions are also detailed. This current volume continues the tradition of providing significant and interesting procedures for synthetic chemists working in increasingly diverse areas.

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Produktdetails

• Verlag: Wiley
• Seitenzahl: 456
• Erscheinungstermin: 4. Januar 2011
• Englisch
• Abmessung: 231mm x 155mm x 25mm
• Gewicht: 703g
• ISBN-13: 9781118005149
• ISBN-10: 1118005147
• Artikelnr.: 32313442

Autorenporträt

Peter Wipf is the Director of the Combinatorial Chemistry Center (CCC) and the Center for Chemical Methodologies and Library Development (UPCMLD) which are involved in many collaborative projects in Chemical Biology. He is also a founding member of the Center for Medical Countermeasures Against Radiation (CMCR) and the University of Pittsburgh Center for Chemical Diversity (UPCDC). He has served on the organizing committee of several conferences and workshops, including the NSF Workshop on Organic Synthesis. He is a member of several editorial boards, including Medicinal Chemistry Letters (ACS MCL), Organic Reactions (OR), and Organic Syntheses (OS).

Inhaltsangabe

Metal-Free One-Pot Oxidative Amination of Aromatic Aldehydes: Conversion of Benzaldehyde to N-Benzoyl Pyrrolidine 1 Kekeli Ekoue-Kovi and Christian Wolf A Practical and Scalable Synthesis of N-Halo Compounds: 2-Chloro-6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline 8 Yong-Li Zhong and Paul G. Bulger Regioselective C-4 Bromination of Oxazoles: 4-Bromo-5-(Thiophen-2-YL) Oxazole 16 Bryan Li, Richard A. Buzon, and Zhijun Zhang Synthesis of Spiroborate Esters from 1,2-Aminoalcohols, Ethylene Glycol and Triisopropyl Borate: Preparation of (S)-1-(1,3,2-Dioxaborolan-2-Yloxy)-3-Methyl-1,1-Diphenylbutan-2-Amine 26 Viatcheslav Stepanenko, Kun Huang and Margarita Ortiz-Marciales Catalytic Enantioselective Borane Reduction of Benzyl Oximes: Preparation of (S)-1-Pyridin-3-YL-Ethylamine BIS Hydrochloride 36 Kun Huang and Margarita Ortiz-Marciales Stereoselective Synthesis of 3-Arylacrylates by Copper-Catalyzed Syn Hydroarylation 53 Naohiro Kirai and Yoshihiko Yamamoto Preparation of (S)-3,3'-BIS-Morpholinomethyl-5,5',6,6',7,7',8,8'-Octahydro-1,1'-BI-2-Naphthol 59 Mark Turlington and Lin Pu Catalytic Asymmetric Addition of an In-Situ Prepared Arylzinc to Cyclohexanecarboxaldehyde: (R)-(+)-
-Cyclohexyl-3-Methoxy-Benzenemethanol 68 Albert M. DeBerardinis, Mark Turlington, and Lin Pu Microwave-Assisted Synthesis of 1,3-Dimesitylimidazolinium Chloride 77 Morgan Hans and Lionel Delaude Synthesis of (3-Chlorobutyl)Benzene by the Cobalt-Catalyzed Hydrochlorination of 4-Phenyl-1-Butene 88 Boris Gaspar, Jerome Waser, and Erick M. Carreira Synthesis of Substituted Indazoles via (3+2) Cycloaddition of Benzyne and Diazo Compounds 95 Feng Shi and Richard C. Larock Palladium-Catalyzed Cross-Coupling Using an Air-Stable Trimethylaluminum Source. Preparation of Ethyl 4-Methylbenzoate 104 Andrej Vinogradov and Simon Woodward Synthesis of Dimethyl 2-Phenycyclopropane-1,1-Dicarboxylate Using an Iodonium Ylide Derived from Dimethyl Malonate 115 Sébastien R. Goudreau, David Marcoux and Andre B. Charette New, Convenient Route for Trifluoromethylation of Steroidal Molecules 126 Xiang-Shu Fei, Wei-Sheng Tian, Kai Ding, Yun Wang and Qing-Yun Chen Preparation of Ethyl 1-Benzyl-4-Fluoropiperidine-4-Carboxylate 137 Jianshe Kong, Tao Meng, Pauline Ting, and Jesse Wong Lithium Amides as Homochiral Ammonia Equivalents for Conjugate Additions to
,ß-Unsaturated Esters: Asymmetric Synthesis of (S)-ß-Leucine 143 Stephen G. Davies, Ai M. Fletcher, and Paul M. Roberts Cyclohexene Imine (7-Aza-Bicyclo[4.1.0]Heptane) 161 Iain D. G. Watson, Nicholas Afagh and Andrei K. Yudin Preparation of (E)-(2-Iodovinyl)Benzene From Benzyl Bromide and Diiodomethane 170 James A. Bull, James J. Mousseau and André B. Charette Synthesis of Tetraorganosilanes: (Chloromethyl)Dimethylphenylsilane 178 Submitted by Kei Murakami, Hideki Yorimitsu, and Koichiro Oshima A General Method for Copper-Catalyzed Arylation of Acidic Arene C-H Bonds. Preparation of 2-Chloro-5-(3-Methylphenyl)-Thiophene 184 Joseph Alvarado, Hien-Quang Do, and Olafs Daugulis 1,3,5-Triacetylbenzene 192 Peter J. Alaimo, Amanda-Lynn Marshall, David M. Andrews and Joseph M. Langenhan Organocatalytic
-Methylenation of Aldehydes: Preparation of 3,7-Dimethyl-2-Methylene-6-Octenal 201 Meryem Benohoud, Anniina Erkkilä, and Petri M. Pihko Ruthenium-Catalyzed Arylation of Ortho C-H Bond in an Aromatic with an Arylboronate: 8-Phenyl-1-Tetralone 209 Kentaroh Kitazawa, Takuya Kochi, and Fumitoshi Kakiuchi Amide Formation by Decarboxylative Condensation of Hydroxylamines and
-Ketoacids: N-[(1S)-1 Phenylethyl]-Benzeneacetamide 218 Lei Ju and Jeffrey W. Bode One-Pot Diazotization and Heck Reaction of Methyl Anthranilate: 2-(3-Oxopropyl) Benzoic Acid Methyl Ester 226 Florencio Zaragoza Synthesis of Ynamides by Copper-Mediated Coupling of 1,1-Dibromo-1-Alkenes with Nitrogen Nucleophiles. Preparation of 4-Methyl-N-(2-Phenylethynyl)-N-(Phenylmethyl)Benzenesulfonamide 231 Alexis Coste, François Couty and Gwilherm Evano Direct Fluorination of the Carbonyl Group of Benzophenones Using Deoxo-Fluor®: Preparation of BIS(4-Fluorophenyl) Difluoromethane 245 Ying Chang, Hyelee Lee, Chulsung Bae Preparation and [2+2] Cycloaddition of 1-Triisopropylsiloxy-1-Hexyne with Methyl Crotonate: 3-Butyl-4-Methyl-2-Triisopropylsiloxy-Cyclobut-2-Enecarboxylic Acid Methyl Ester 253 Valeriy Shubinets, Michael P. Schramm, and Sergey A. Kozmin Pd(0)-Catalyzed Asymmetric Allylic and Homoallylic Diamination of 4-Phenyl-1-Butene with DI-Tert-Butyldiaziridinone 263 Baoguo Zhao, Haifeng Du, Renzhong Fu, and Yian Shi Synthesis of Enamides from Ketones: Preparation of N-(3,4-Dihydronaphthalene-1-YL)Acetamide 275 Hang Zhao, Charles P. Vandenbossche, Stefan G. Koenig, Surendra P. Singh, and Roger P. Bakale Safe and Scalable Preparation of Barluenga's Reagent 288 Justin M. Chalker, Amber L. Thompson, and Benjamin G. Davis Palladium-Catalyzed Alkyl-Alkyl Suzuki Cross-Couplings of Primary Alkyl Bromides at Room Temperature: (13-Chlorotridecyloxy)Triethylsilane 299 Sha Lou and Gregory C. Fu Synthesis of Chiral Pyridine Bis(Oxazoline) Ligands for Nickel-Catalyzed Asymmetric Negishi Cross-Couplings of Secondary allylic Chlorides with Alkylzincs:2,6-BIS[(4R)-4,5-Dihydro-4-(2-Phenylethyl)-2-Oxazolyl]-Pyridine 310 Sha Lou and Gregory C. Fu Nickel-Catalyzed Asymetric Negishi Cross-Couplings of Racemic Secondary Allylic Chlorides with Alkylzincs: (S,E)-Ethyl 6-(1,3-Dioxolan-2-YL)-4-Methylhex-2-Enoate 317 Sha Lou and Gregory C. Fu Nickel-Catalyzed Enantioselective Negishi Cross-Couplings of Racemic Secondary a-Bromo Amides with Alkylzinc Reagents: (s)-N-Benzyl-7-Cyano-2-Ethyl-N-Phenylheptanamide 330 Sha Lou and Gregory C. Fu One-Pot Synthesis of 5H-Indazolo-[3,2-b] Benzo[d]-1,3-Oxazine: Two Efficient Preparative Methods 339 Danielle M. Solano, Jeffrey D. Butler, Makhluf J. Haddadin and Mark J. Kurth Preparation of Chiral and Achiral Triazolium Salts: Carbene Precursors with Demonstrated Synthesis Utility 350 Harit U. Vora, Stephen P. Lathrop, Nathan T. Reynolds, Mark S. kerr, Javier Read de Alaniz, and Tomislav Rovis Synthesis of A N-Mesityl Substituted Aminoindanol-Derived Triazolium Salt 362 Justin R. Struble and Jeffrey W. Bode Preparation of O-Allyl-N-(9-Anthracenyl-Methyl)-Cinchonidium Bromide as a Phase Transfer Catalyst 377 E. J. Corey and Mark C. Noe