Organic Syntheses, Volume 90

Herausgeber: Hughes, David

• Gebundenes Buch

Produktbeschreibung

The current volume continues the tradition of providing significant and interesting procedures, which should prove worthwhile to many synthetic chemists working in increasingly diverse areas. Following precedent, there is no specific or central theme to this volume.

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Produktdetails

• Verlag: Wiley
• Seitenzahl: 424
• Erscheinungstermin: 28. April 2014
• Englisch
• Abmessung: 231mm x 155mm x 28mm
• Gewicht: 680g
• ISBN-13: 9781118893845
• ISBN-10: 1118893840
• Artikelnr.: 40106267

Autorenporträt

David Hughes obtained his Ph.D. in physical organic chemistry under the direction of Professor Fred Bordwell at Northwestern University in 1981. After post-doctoral work in the laboratory of Professor Ned Arnett at Duke University, he joined the Process Research department of Merck Research Laboratories in 1982 and currently holds the position of Executive Director, Scientific Staff. His area of expertise is physical organic chemistry with a focus on elucidation of mechanisms of synthetically important organic reactions. In the mid-1990's, the Hughes group took on the challenge of developing a viable synthesis of a semi-synthetic pneumocandin antifungal candidate that was entering development at that time. This development candidate progressed through many hurdles and was ultimately approved under the trademark CANCIDAS in 2001. Along with his colleagues Robert Schwartz and Jim Balkovec, Dave was awarded the 2006 ACS Heroes of Chemistry Award for this work. Other Merck drugs that Dave has been instrumental in process design and development include Primaxin, Emend, and Cozaar. Dave has co-authored over 100 papers and has been a member of the editorial board for Organic Synthesis since 2008.

Inhaltsangabe

Synthesis of Koser's Reagent and Derivatives Reagent for Divalent Sulfur Protection: Preparation of 4
Methylbenzenesulfonothioic Acid, S
[(1,1
Dimethylethyl)
Dimethylsilyl]oxy]methyl] Ester Discussion Addendum for: Applications of (2S)
3
exo
Morpholinoisoborneol [MIB] in Organic Synthesis Preparation of (E)
N, N
Diethyl
2
styrylbenzamide by Rh
Catalyzed C
H Activation Enantioselective Nitroaldol (Henry) Reaction of p
Nitrobenzaldehyde and Nitromethane Using a Copper (II) Complex Derived from (R, R)
1,2
Diaminocyclohexane: (1S)
1
(4
Nitrophenyl)
2
nitroethane
1
ol Synthesis of N
Acetyl Enamides by Reductive Acetylation of Oximes Mediated with Iron(II) Acetate: N
(1
(4
Bromophenyl)vinyl)acetamide Oxindole Synthesis via Palladium
catalyzed C
H Functionalization Intermolecular retro
Cope Type Hydroxylamination of Alkynes with NH2OH: E
1
(1
Hydroxycyclohexyl)ethanone oxime Preparation of 1,5
Disubstituted 1,2,3
Triazoles via Ruthenium
catalyzed Azide Alkyne Cycloaddition Discussion Addendum for: Nickel
catalyzed Homoallylation of Aldehydes with 1,3
Dienes Enantioselective Alkylation of N
(Diphenylmethylene)glycinate tert
Butyl Ester: Synthesis of (R)
2
(Benzhydrylidenamino)
3
Phenylpropanoic Acid tert
Butyl Ester Enantioselective Alkylation of 2
[(4
Chlorobenzyliden)Amino]Propanoic Acid tert
Butyl Ester: Synthesis of (R)
2
Amino
2
Methyl
3
Phenylpropanoic Acid tert
Butyl Ester Preparation of ¿
Fluorobis(phenylsulfonyl)methane (FBSM) Direct Conversion of Benzylic and Allylic Alcohols to Diethyl Phosphonates Synthesis of 1
Naphthol via Oxidation of Potassium 1
Naphthyltrifluoroborate Potassium tert
Butoxide Mediated Synthesis of Phenanthridinone Preparation of N1
Phenylacetamidine 4
Bromobenzoate Using 2,2,2
Trichloroethyl Acetimidate Hydrochloride Phenylacetamidine 4
Bromobenzoate Using 2,2,2
Trichloroethyl Acetimidate Hydrochloride Discussion Addendum for: Stereoselective Synthesis of anti alpha
Methyl
beta
Methoxy Carboxylic Compounds Bimolecular Oxidative Amidation of Phenols: 1
(Acetylamino)
4
oxo
2,5
cyclohexadiene
1
acetic acid, Methyl Ester Nickel
Catalyzed Cross
Coupling of Aryl Halides with Alkyl Halides: Ethyl 4
(4
(4
methylphenylsulfonamido)
phenyl)butanoate Synthesis of 1
Naphthol via Oxidation of Potassium 1
Naphthyltrifluoroborate Potassium tert
Butoxide Mediated Synthesis of Phenanthridinone Preparation of N1
Phenylacetamidine 4
Bromobenzoate Using 2,2,2
Trichloroethyl Acetimidate Hydrochloride Discussion Addendum for: Stereoselective Synthesis of anti [alpha]
Methyl
[beta]
Methoxy Carboxylic Compounds Bimolecular Oxidative Amidation of Phenols: 1
(Acetylamino)
4
oxo
2,5
cyclohexadiene
1
acetic acid, Methyl Ester Nickel
Catalyzed Cross
Coupling of Aryl Halides with Alkyl Halides: Ethyl 4
(4
(4
methylphenylsulfonamido)
phenyl)butanoate Discussion Addendum for: Preparation of 4
Acetylamino
2, 2, 6, 6
tetramethylpiperidine
1
oxoammonium Tetrafluoroborate and the Oxidation of Geraniol to Geranial (2,6
Octadienal, 3,7
dimethyl
, (2e)
) Preparation of 3
Oxocyclohex
1
ene
1
carbonitrile Air Oxidation of Primary Alcohols Catalyzed by Copper(I)/TEMPO. Preparation of 2
Amino
5
bromo
benzaldehyde One
Pot Preparation of Cyclic Amines from Amino Alcohols Preparation of Tetrabutylammonium (4
fluorophenyl)trifluoroborate Allyl Cyanate
To
Isocyanate Rearrangement: Preparation of tert
Butyl 3,7
Dimethylocta
1,6
dien
3
ylcarbamate Palladium
Catalyzed Triazolopyridine Synthesis: Synthesis of 7
Chloro
3
(2
Chlorophenyl)
1,2,4
Triazolo[4,3
a]Pyridine Preparation of DABSO from Karl
Fischer Reagent Low
epimerization Peptide Bond Formation with Oxyma Pure: Preparation of Z
L
Phg
Val
OMe Practical Synthesis of Di
tert
Butyl
Phosphinoferrocene Preparation of 1
Benzyl
2
methyl
3
(ethoxycarbonyl)
4
(2
phenylethyl)
1H
pyrrole from 4
Phenyl
1,2
butadiene Synthesis of Highly Enantiomerically Enriched Amines by Asymmetric Transfer Hydrogenation of N
(tert
Butylsulfinyl)Imines Simplified Preparation of Dimethyldioxirane (DMDO) Practical and Efficient Synthesis of N
Formylbenzotriazole