Studies have established that there is lack of adequate understanding of how organisational characteristics influence the health and safety (H&S) practices of small and medium-sized construction companies (construction SMEs). This necessitated the evaluation of the influence of organisational characteristics on H&S practices of construction SMEs with a view to determining favourable conditions for effective safety performance. The use of mixed methods approach was adopted for the study. The research data were collected with the use of questionnaires and observation. Results of the study revealed that the organisational characteristics of construction SMEs are significant predictors of H&S practices. It was concluded that organisational characteristics have significant influence on the H&S practices of the Nigerian construction SMEs. It was recommended that construction stakeholders should develop positive attitude and commitment towards H&S management.