Information and communication technology (ICT) skills have becoming the basic requirement for individuals to compete in the global market. Technology has incredible power to improve people's lives, to foster economic growth, and to create opportunities for individuals, companies, and nations around the globe. Over the past 13 years, the transformation of information and communication technologies has been well documented. The transformation of ICT has resulted in the emergence of new challenges to employees and on employment matters. Issues such as brain drain, workmen compensation, treatment of foreign workers, terms of employment and organizational safety and health and new ways of working methods have taken on new dimensions and may necessitate changes to the existing regulation. Hence, theses challenges require new work culture and create increasing job stress among employees which visibly affects the moral and efficiency of the employees. The purpose of this study thus, is to examine the relationship between the organizational culture and job efficiency with the intervening variables of job stress and employee morale among employees in the ICT industries in Malaysia.