Osteoarthritis of knee joints is now a days the most common Musculoskeletal disorders. Among women, it is very common. It can cause deformities and can hamper day to day activities. In modern science, no satisfactory results of Osteoarthritis has been established. Ayurveda meditation and Panchkarma procedures are very effective to reduce symptoms of Osteoarthritis and improve quality of life. Rasayana or Rejuvenative therapy is the most important as well as necessary for degenerative disorders.