Osteofibrous dysplasia is a rare, benign non-neoplastic condition with no known cause. It is considered a fibrovascular defect. Campanacci described this condition in two leg bones, the tibia and fibula, and coined the term. In 1942, however, Jaffe and Lichtenstein described the same condition under the name "nonosteogenic fibroma", so the condition is often known as Jaffe-Campanacci Syndrome. The syndrome's exact nature is under debate, with some authors suggesting that it may be a manifestation of neurofibromatosis.The tibia is the most commonly involved bone, accounting for 85% of cases.
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