Osteoimmunology

Interactions of the Immune and Skeletal Systems
Herausgeber: Lorenzo, Joseph; Schett, Georg; Takayanagi, Hiroshi; Choi, Yongwon; Horowitz, Mark

• Gebundenes Buch

Produktbeschreibung

Osteoimmunology: Interactions of the Immune and Skeletal Systems, Second Edition, explores the advancements that have been made in the field during the last 40 years, including valuable information on our understanding of the interactions between hematopoietic, immune, and bone cells, now known as the field of osteoimmunology. This comprehensive work offers the most extensive summaries of research trends in the field and their translation into new therapeutics. Early chapters deal with the development of osteoblasts, osteoclasts, hematopoietic stem cells, T and B-lymphocytes, and communications between these cellular elements, while later sections contain discussions of the signaling pathways by which RANKL influences osteoclast development and function. Subsequent chapters explore the effects that estrogen has on bone and the immune system, the development of pathologic conditions, and the growing research around osteoporosis, Paget's disease, the genetics of bone disease, and bone cancer metastasis.

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Produktdetails

• Verlag: Elsevier Science
• 2nd Revised edition
• Seitenzahl: 376
• Erscheinungstermin: 6. Oktober 2015
• Englisch
• Abmessung: 279mm x 218mm x 23mm
• Gewicht: 1270g
• ISBN-13: 9780128005712
• ISBN-10: 0128005718
• Artikelnr.: 42885172

Inhaltsangabe

1. Overview
2. Origins of the Osteoclast
3. Trafficking of Osteoclast Precursors
4. Osteoclast Biology: Regulation of Formation and Function
5. Osteoblasts and the Immune system
6. Osteocyte Biology
7. Bone Cells and the Hematopoietic Niche
8. The Function of RANKL Beyond the Osteoclast
9. The Effects of Immune Cell Products (Cytokines and Hematopoietic Cell
Growth Factors) on Bone Cells
10. Coupling Between Immune and Bone Cells
11. The Role of the Immune System in the Development of Osteoporosis and
Fracture Risk
12. The Role of Sex Steroiods in the Interactions of the Immune System with
Bone
13. The Role of the Immune System in the Local and Systemic Bone Loss of
Inflammatory Arthritis
14. Osteoarthritis and the Immune System
15. Inflammatory Bowel Disease and Bone
16. The Role of the Immune System and Bone Cells in Acute and Chronic
Osteomyelitis
17. The Role of the Immune System in Fracture Healing
18. The Role of the Immune System in the Effects of Cancer on Bone
19. Osteoimmunology in the Oral Cavity (Periodontal Disease, Lesions of
Endodontic Origin and Orthodontic Tooth Movement)
20. The Role of the Immune System in the Interactions of Fat and Bone