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Osteoporosis is a chronic disease affecting millions of people worldwide and is characterized by compromised bone strength predisposing to increased risk of fracture. Modern discoveries in bone biology demonstrate that Receptor Activator of Nuclear factor kappa-B Ligand (RANKL) is an essential mediator of osteoclast formation, function and survival with Wnt signaling involvement. New biologic therapies are used to treat various autoimmune diseases and recently for osteoporosis. This book throws light on the new era in the management of osteoporosis and on the new biologic agents with potential therapeutic effects. The book presents an overview on the basic concepts of osteoporosis and the evolution of biologic therapies. It is designed to provide a useful and informative outline for medical students and professionals and the content is sufficiently comprehensive serving as a reference for clinicians dealing with osteoporosis patients. Readers will take a worthy idea on the disease and the advanced concepts in its management. This book should prove useful in throwing light on biologic therapy and its role in osteoporosis, and in translating these concepts to improve human health.