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The book summarizes recent advances in the elucidation of the mechanisms involved in senile osteoporosis as well as its potential treatment, bringing an integrated approach from the bench to the clinical practice. A unique aspect of this book is its emphasis on the application of translational research in the field of osteoporosis and falls. The book provides a complete review on the prevention as well as current and future treatments of osteoporosis.
Although osteoporosis has been de? ned as "a metabolic bone disease characterized by low bone mass and microarchitectural deterioration of bone tissue leading to enhanced bone fragility and a consequent increase in fracture risk," it is not clear that osteoporosis represents a single disease as much as a similar response of bone to different pathophysiologies. In the 1940s Fuller Albright and colleagues recognized "osteoporosis of old age" and distinguished it from osteoporosis associated with the postme- pausal state, as well as from osteoporosis from disuse, osteoporosis from malnutrition, and other forms of osteoporosis. He nevertheless pointed out that it was unclear how much of osteoporosis is due to old age per se, in view of the fact that "in many cases osteoporosis of disuse, of malnutrition, of the postmenopausal state and of senility are inseparably superimposed. " In this volume, Duque and Kiel have gathered an international panel of experts to highlight the unique features of senile osteoporosis and cons- eration of this disease spans the very basic through the clinical and the epidemiologic. As an organ which harbors stem cells, bone may clearly in? uence not only its own regeneration but also the regeneration of other tissues, notably the hematopoietic system.
Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Although osteoporosis has been de? ned as "a metabolic bone disease characterized by low bone mass and microarchitectural deterioration of bone tissue leading to enhanced bone fragility and a consequent increase in fracture risk," it is not clear that osteoporosis represents a single disease as much as a similar response of bone to different pathophysiologies. In the 1940s Fuller Albright and colleagues recognized "osteoporosis of old age" and distinguished it from osteoporosis associated with the postme- pausal state, as well as from osteoporosis from disuse, osteoporosis from malnutrition, and other forms of osteoporosis. He nevertheless pointed out that it was unclear how much of osteoporosis is due to old age per se, in view of the fact that "in many cases osteoporosis of disuse, of malnutrition, of the postmenopausal state and of senility are inseparably superimposed. " In this volume, Duque and Kiel have gathered an international panel of experts to highlight the unique features of senile osteoporosis and cons- eration of this disease spans the very basic through the clinical and the epidemiologic. As an organ which harbors stem cells, bone may clearly in? uence not only its own regeneration but also the regeneration of other tissues, notably the hematopoietic system.
Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
From the reviews:
"The authors of this multiauthored book bring together new information on the molecular biology of bone physiology in this examination of osteoporosis in older persons. ... The intended audience includes all health practitioners who treat older patients with osteoporosis. Research scientists in the area will find this book useful as well. ... This book's demonstration of the complex relationship of bone health to adipose tissue and several powerful hormones will stimulate new thinking in the area of osteoporosis." (David O. Staats, Doody's Review Service, August, 2008)
"This is a simply outstanding compilation that provides a clear and concise review of the effect age has on the skeleton at the molecular/genetic level, in animal models as well as humans. ... It provides clinicians with an overview of cellular mechanisms leading to bone loss and researchers with insight into the clinical consequences of age-related skeletal change in older adults. That such a text has not previously been written and become a reference standard among clinicians, geriatricians, and researchers ... ." (Neil Binkley, JAMA, Vol. 300 (11), September, 2008)
"The authors of this multiauthored book bring together new information on the molecular biology of bone physiology in this examination of osteoporosis in older persons. ... The intended audience includes all health practitioners who treat older patients with osteoporosis. Research scientists in the area will find this book useful as well. ... This book's demonstration of the complex relationship of bone health to adipose tissue and several powerful hormones will stimulate new thinking in the area of osteoporosis." (David O. Staats, Doody's Review Service, August, 2008)
"This is a simply outstanding compilation that provides a clear and concise review of the effect age has on the skeleton at the molecular/genetic level, in animal models as well as humans. ... It provides clinicians with an overview of cellular mechanisms leading to bone loss and researchers with insight into the clinical consequences of age-related skeletal change in older adults. That such a text has not previously been written and become a reference standard among clinicians, geriatricians, and researchers ... ." (Neil Binkley, JAMA, Vol. 300 (11), September, 2008)
Aus den Rezensionen:
"... Ziel der Autoren ist es, die Leser mit neuesten Informationen über die Osteoporose des betagten Menschen zu versorgen. ... Das Buch zeichnet aus, dass klar und übersichtlich die Verbindung zwischen Altern und den dazugehörigen Veränderungen in der Knochenbiologie aufgezeichnet werden ... Zudem werden in ... Abbildungen die ... therapeutischen Ziele zur Prävention und zur Behandlung der senilen Osteoporose aufgezeigt ... lnsgesamt ein Buch, das sich an Geriater, Orthopäden und ... anderen medizinischen Berufsgruppen wendet, die sich mit der medikamentösen Osteoporose und Sturzprophylaxe des geriatrischen Patienten beschäftigen ..." -- Prof. Dr. Bernd Fromm, in: Orthopädie Mitteilungen, 2009, Issue 1, S. 117 f.
"... Ziel der Autoren ist es, die Leser mit neuesten Informationen über die Osteoporose des betagten Menschen zu versorgen. ... Das Buch zeichnet aus, dass klar und übersichtlich die Verbindung zwischen Altern und den dazugehörigen Veränderungen in der Knochenbiologie aufgezeichnet werden ... Zudem werden in ... Abbildungen die ... therapeutischen Ziele zur Prävention und zur Behandlung der senilen Osteoporose aufgezeigt ... lnsgesamt ein Buch, das sich an Geriater, Orthopäden und ... anderen medizinischen Berufsgruppen wendet, die sich mit der medikamentösen Osteoporose und Sturzprophylaxe des geriatrischen Patienten beschäftigen ..." -- Prof. Dr. Bernd Fromm, in: Orthopädie Mitteilungen, 2009, Issue 1, S. 117 f.