High Quality Content by WIKIPEDIA articles! Oxford is a city and the county seat of Lafayette County, Mississippi, United States. Founded in 1835, it was named after the British university city of Oxford in hopes of having the state university located there, which it did successfully attract. The population is about 19,000, due to the city's recent annexation of five square miles of Lafayette County in all directions. Oxford is the home of the University of Mississippi, founded in 1848, also known as "Ole Miss."