P. Elsner / J. Thiele (eds.)
Oxidants and Antioxidants in Cutaneous Biology
Herausgegeben von Thiele, J.; Elsner, P.; Itin, P.; Jemec, G. B. E.
P. Elsner / J. Thiele (eds.)
Oxidants and Antioxidants in Cutaneous Biology
Herausgegeben von Thiele, J.; Elsner, P.; Itin, P.; Jemec, G. B. E.
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Are free radicals and reactive oxygen species relevant to dermatopathology? Do antioxidants protect against free-radical-mediated cutaneous diseases and aging? To these and further current questions in the rapidly progressing field of basic and applied skin research, this up-to-date volume provides a scientific basis. It presents state-of-the-art reviews on the progress in detection of free radicals and antioxidants and their responses to environmental oxidative stressors. Furthermore, several expert contributions focus on the exciting developments in oxidative DNA damage and UVB- and…mehr
Are free radicals and reactive oxygen species relevant to dermatopathology? Do antioxidants protect against free-radical-mediated cutaneous diseases and aging? To these and further current questions in the rapidly progressing field of basic and applied skin research, this up-to-date volume provides a scientific basis. It presents state-of-the-art reviews on the progress in detection of free radicals and antioxidants and their responses to environmental oxidative stressors. Furthermore, several expert contributions focus on the exciting developments in oxidative DNA damage and UVB- and UVA-induced signal transduction in skin. Finally, information is given on new antioxidant protection strategies against skin carcinogenesis and skin aging which may be fundamental for the pharmaceutical or skin-care products of tomorrow. Due to its unique and up-to-date collection of state-of-the-art contributions by many of the world's leading scientists in the field, this book will be essential reading for dermatologists, cosmetologists, pharmacologists and environmental toxicologists.
Produktdetails
- Produktdetails
- Current Problems in Dermatology Vol.29
- Verlag: Karger
- 2000.
- Seitenzahl: 194
- Englisch
- Abmessung: 250mm
- Gewicht: 558g
- ISBN-13: 9783805571326
- ISBN-10: 3805571321
- Artikelnr.: 09527373
- Current Problems in Dermatology Vol.29
- Verlag: Karger
- 2000.
- Seitenzahl: 194
- Englisch
- Abmessung: 250mm
- Gewicht: 558g
- ISBN-13: 9783805571326
- ISBN-10: 3805571321
- Artikelnr.: 09527373
Jens Thiele, geboren 1944 in Potsdam, studierte Freie Graphik und Kunstpädagogik an der Kunstakademie Braunschweig und Kunstwissenschaft in Göttingen, wo er über Das Kunstwerk im Film promovierte. Er arbeitete als Kunsterzieher in Göttingen und als wissenschaftlicher Assistent an der Bergischen Universität in Wuppertal bevor er Professor für Visuelle Medien an der Carl von Ossietzky-Universität in Oldenburg wurde. Hier ist er Direktor der Forschungsstelle Kinder- und Jugendliteratur. Schwerpunkte in Forschung und Lehre: Geschichte, Theorie und Ästhetik visueller Medien, insbesondere des Bilderbuchs und des Spielfilms.
1;Contents;7
2;Preface;9
3;Detection of Free Radicals in Skin: A Review of the Literature and New Developments;10
3.1;Direct Detection of Free Radicals;11
3.2;Indirect Detection of Free Radicals;11
3.3;Nitroxide-Based Electron Paramagnetic Resonance;12
3.4;Electron Paramagnetic Resonance Imaging;16
3.5;In vivo Electron Paramagnetic Resonance;17
3.6;Outlook;21
3.7;References;21
4;Electron Paramagnetic Resonance Detection of Free Radicals in UV-Irradiated Human and Mouse Skin;27
4.1;Materials and Methods;28
4.2;Results;28
4.3;Discussion;31
4.4;References;32
5;The Antioxidant Network of the Stratum corneum;35
5.1;Physiological Levels of Antioxidants in the Stratum corneum;35
5.2;Impact of Environmental Factors on Barrier-Antioxidants;37
5.3;Clinical Implications of Oxidative Stress in the Stratum corneum;43
5.4;Synopsis;48
5.5;Acknowledgements;49
5.6;References;49
6;Activity of Alpha-Lipoic Acid in the Protection against Oxidative Stress in Skin;52
6.1;Materials and Methods;53
6.2;Results and Discussion;54
6.3;Conclusion;58
6.4;Acknowledgments;58
6.5;References;59
7;Ozone: An Emerging Oxidative Stressor to Skin;61
7.1;O3 Reacts in the Stratum corneum;61
7.2;O3 Depletes Hydrophilic Antioxidants;63
7.3;O3-Induces Damage to Biomolecules;63
7.4;O3 and UV Radiation Have Additive Effects;65
7.5;Potential Pathophysiological Consequences of Topical O3 Exposure;66
7.6;Conclusion;68
7.7;References;68
8;Effects of UV and Visible Radiations on Cellular DNA;71
8.1;DNA Photoproducts Arising from Direct UVB Excitation;72
8.2;UVA- and Visible-Radiation-Mediated Oxidative Damage to DNA;74
8.3;Measurement of UVA- and Visible-Light-Mediated Formation of Oxidized Bases and Strand Breaks within Cellular DNA;77
8.4;Conclusions and Future Directions;79
8.5;References;80
9;Sequence-Specific DNA Damage Induced by UVA Radiation in the Presence of Endogenous and Exogenous Photosensitizers;83
9.1;Type I Mechanism;85
9.2;Major Type II Mechanism;88
9.3;Minor Type II Mechanism;89
9.4;Role of UVA-Induced Oxidative DNA Damage in Mutagenesis;89
9.5;References;90
10;UV-Induced Oxidative Stress and Photoaging;92
10.1;Clinical and Biochemical Features in Photoaging;93
10.2;UV-Generated Oxidative Stress Drives Photoaging;94
10.3;UV-Induced Reactive Oxygen Species and Their Damaging Effect on Structural Dermal Proteins;95
10.4;UV-Induced Reactive Oxygen Species and Their Damaging Effects on the Cellular Component of Dermal Connective Tissue;98
10.5;Perspectives;100
10.6;References;100
11;UVA and Singlet Oxygen as Inducers of Cutaneous Signaling Events;104
11.1;Generation of Singlet Oxygen in vivo;105
11.2;Singlet Oxygen as Mediator of UVA-Induced Signaling;108
11.3;Signaling Induced by Photodynamic Therapy;111
11.4;UVA, PDT, Singlet Oxygen and Apoptosis;113
11.5;Conclusion;116
11.6;Acknowledgements;116
11.7;References;116
12;Reactive Oxygen Species as Mediators of UVB-Induced Mitogen-Activated Protein Kinase Activation in Keratinocytes;123
12.1;Mitogen-Activated Protein Kinases Induced by UVB;124
12.2;Reactive Oxygen Species: Mediators of UVB-Induced Mitogen-Activated Protein Kinase Activation;126
12.3;Antioxidants in the Regulation of UVB-Induced Mitogen-Activated Protein Kinase Activation;128
12.4;Role of UVB-Induced Extracellular Signal-Regulated Kinase Activation in Cell Survival;129
12.5;Mitogen-Activated Protein Kinase Activation: Dependence on Epidermal Growth Factor Receptor Phosphorylation;130
12.6;Phosphatases: Regulators of Mitogen-Activated Protein Kinase;131
12.7;Perspective;132
12.8;Acknowledgment;132
12.9;References;132
13;Antioxidants in Chemoprevention of Skin Cancer;137
13.1;Skin Cancer Development and Antioxidants;138
13.2;Skin Cancer Chemoprevention by NaturallyOccurring Antioxidants;139
13.3;Conclusion;146
13.4;References;147
14;Radical Reactions of Carotenoids and Potential In.uence on UV Carcinogenesis;149
14.1;Radical Reactions of Carotenoids;151
14.2;Epidemiologica
2;Preface;9
3;Detection of Free Radicals in Skin: A Review of the Literature and New Developments;10
3.1;Direct Detection of Free Radicals;11
3.2;Indirect Detection of Free Radicals;11
3.3;Nitroxide-Based Electron Paramagnetic Resonance;12
3.4;Electron Paramagnetic Resonance Imaging;16
3.5;In vivo Electron Paramagnetic Resonance;17
3.6;Outlook;21
3.7;References;21
4;Electron Paramagnetic Resonance Detection of Free Radicals in UV-Irradiated Human and Mouse Skin;27
4.1;Materials and Methods;28
4.2;Results;28
4.3;Discussion;31
4.4;References;32
5;The Antioxidant Network of the Stratum corneum;35
5.1;Physiological Levels of Antioxidants in the Stratum corneum;35
5.2;Impact of Environmental Factors on Barrier-Antioxidants;37
5.3;Clinical Implications of Oxidative Stress in the Stratum corneum;43
5.4;Synopsis;48
5.5;Acknowledgements;49
5.6;References;49
6;Activity of Alpha-Lipoic Acid in the Protection against Oxidative Stress in Skin;52
6.1;Materials and Methods;53
6.2;Results and Discussion;54
6.3;Conclusion;58
6.4;Acknowledgments;58
6.5;References;59
7;Ozone: An Emerging Oxidative Stressor to Skin;61
7.1;O3 Reacts in the Stratum corneum;61
7.2;O3 Depletes Hydrophilic Antioxidants;63
7.3;O3-Induces Damage to Biomolecules;63
7.4;O3 and UV Radiation Have Additive Effects;65
7.5;Potential Pathophysiological Consequences of Topical O3 Exposure;66
7.6;Conclusion;68
7.7;References;68
8;Effects of UV and Visible Radiations on Cellular DNA;71
8.1;DNA Photoproducts Arising from Direct UVB Excitation;72
8.2;UVA- and Visible-Radiation-Mediated Oxidative Damage to DNA;74
8.3;Measurement of UVA- and Visible-Light-Mediated Formation of Oxidized Bases and Strand Breaks within Cellular DNA;77
8.4;Conclusions and Future Directions;79
8.5;References;80
9;Sequence-Specific DNA Damage Induced by UVA Radiation in the Presence of Endogenous and Exogenous Photosensitizers;83
9.1;Type I Mechanism;85
9.2;Major Type II Mechanism;88
9.3;Minor Type II Mechanism;89
9.4;Role of UVA-Induced Oxidative DNA Damage in Mutagenesis;89
9.5;References;90
10;UV-Induced Oxidative Stress and Photoaging;92
10.1;Clinical and Biochemical Features in Photoaging;93
10.2;UV-Generated Oxidative Stress Drives Photoaging;94
10.3;UV-Induced Reactive Oxygen Species and Their Damaging Effect on Structural Dermal Proteins;95
10.4;UV-Induced Reactive Oxygen Species and Their Damaging Effects on the Cellular Component of Dermal Connective Tissue;98
10.5;Perspectives;100
10.6;References;100
11;UVA and Singlet Oxygen as Inducers of Cutaneous Signaling Events;104
11.1;Generation of Singlet Oxygen in vivo;105
11.2;Singlet Oxygen as Mediator of UVA-Induced Signaling;108
11.3;Signaling Induced by Photodynamic Therapy;111
11.4;UVA, PDT, Singlet Oxygen and Apoptosis;113
11.5;Conclusion;116
11.6;Acknowledgements;116
11.7;References;116
12;Reactive Oxygen Species as Mediators of UVB-Induced Mitogen-Activated Protein Kinase Activation in Keratinocytes;123
12.1;Mitogen-Activated Protein Kinases Induced by UVB;124
12.2;Reactive Oxygen Species: Mediators of UVB-Induced Mitogen-Activated Protein Kinase Activation;126
12.3;Antioxidants in the Regulation of UVB-Induced Mitogen-Activated Protein Kinase Activation;128
12.4;Role of UVB-Induced Extracellular Signal-Regulated Kinase Activation in Cell Survival;129
12.5;Mitogen-Activated Protein Kinase Activation: Dependence on Epidermal Growth Factor Receptor Phosphorylation;130
12.6;Phosphatases: Regulators of Mitogen-Activated Protein Kinase;131
12.7;Perspective;132
12.8;Acknowledgment;132
12.9;References;132
13;Antioxidants in Chemoprevention of Skin Cancer;137
13.1;Skin Cancer Development and Antioxidants;138
13.2;Skin Cancer Chemoprevention by NaturallyOccurring Antioxidants;139
13.3;Conclusion;146
13.4;References;147
14;Radical Reactions of Carotenoids and Potential In.uence on UV Carcinogenesis;149
14.1;Radical Reactions of Carotenoids;151
14.2;Epidemiologica
1;Contents;7
2;Preface;9
3;Detection of Free Radicals in Skin: A Review of the Literature and New Developments;10
3.1;Direct Detection of Free Radicals;11
3.2;Indirect Detection of Free Radicals;11
3.3;Nitroxide-Based Electron Paramagnetic Resonance;12
3.4;Electron Paramagnetic Resonance Imaging;16
3.5;In vivo Electron Paramagnetic Resonance;17
3.6;Outlook;21
3.7;References;21
4;Electron Paramagnetic Resonance Detection of Free Radicals in UV-Irradiated Human and Mouse Skin;27
4.1;Materials and Methods;28
4.2;Results;28
4.3;Discussion;31
4.4;References;32
5;The Antioxidant Network of the Stratum corneum;35
5.1;Physiological Levels of Antioxidants in the Stratum corneum;35
5.2;Impact of Environmental Factors on Barrier-Antioxidants;37
5.3;Clinical Implications of Oxidative Stress in the Stratum corneum;43
5.4;Synopsis;48
5.5;Acknowledgements;49
5.6;References;49
6;Activity of Alpha-Lipoic Acid in the Protection against Oxidative Stress in Skin;52
6.1;Materials and Methods;53
6.2;Results and Discussion;54
6.3;Conclusion;58
6.4;Acknowledgments;58
6.5;References;59
7;Ozone: An Emerging Oxidative Stressor to Skin;61
7.1;O3 Reacts in the Stratum corneum;61
7.2;O3 Depletes Hydrophilic Antioxidants;63
7.3;O3-Induces Damage to Biomolecules;63
7.4;O3 and UV Radiation Have Additive Effects;65
7.5;Potential Pathophysiological Consequences of Topical O3 Exposure;66
7.6;Conclusion;68
7.7;References;68
8;Effects of UV and Visible Radiations on Cellular DNA;71
8.1;DNA Photoproducts Arising from Direct UVB Excitation;72
8.2;UVA- and Visible-Radiation-Mediated Oxidative Damage to DNA;74
8.3;Measurement of UVA- and Visible-Light-Mediated Formation of Oxidized Bases and Strand Breaks within Cellular DNA;77
8.4;Conclusions and Future Directions;79
8.5;References;80
9;Sequence-Specific DNA Damage Induced by UVA Radiation in the Presence of Endogenous and Exogenous Photosensitizers;83
9.1;Type I Mechanism;85
9.2;Major Type II Mechanism;88
9.3;Minor Type II Mechanism;89
9.4;Role of UVA-Induced Oxidative DNA Damage in Mutagenesis;89
9.5;References;90
10;UV-Induced Oxidative Stress and Photoaging;92
10.1;Clinical and Biochemical Features in Photoaging;93
10.2;UV-Generated Oxidative Stress Drives Photoaging;94
10.3;UV-Induced Reactive Oxygen Species and Their Damaging Effect on Structural Dermal Proteins;95
10.4;UV-Induced Reactive Oxygen Species and Their Damaging Effects on the Cellular Component of Dermal Connective Tissue;98
10.5;Perspectives;100
10.6;References;100
11;UVA and Singlet Oxygen as Inducers of Cutaneous Signaling Events;104
11.1;Generation of Singlet Oxygen in vivo;105
11.2;Singlet Oxygen as Mediator of UVA-Induced Signaling;108
11.3;Signaling Induced by Photodynamic Therapy;111
11.4;UVA, PDT, Singlet Oxygen and Apoptosis;113
11.5;Conclusion;116
11.6;Acknowledgements;116
11.7;References;116
12;Reactive Oxygen Species as Mediators of UVB-Induced Mitogen-Activated Protein Kinase Activation in Keratinocytes;123
12.1;Mitogen-Activated Protein Kinases Induced by UVB;124
12.2;Reactive Oxygen Species: Mediators of UVB-Induced Mitogen-Activated Protein Kinase Activation;126
12.3;Antioxidants in the Regulation of UVB-Induced Mitogen-Activated Protein Kinase Activation;128
12.4;Role of UVB-Induced Extracellular Signal-Regulated Kinase Activation in Cell Survival;129
12.5;Mitogen-Activated Protein Kinase Activation: Dependence on Epidermal Growth Factor Receptor Phosphorylation;130
12.6;Phosphatases: Regulators of Mitogen-Activated Protein Kinase;131
12.7;Perspective;132
12.8;Acknowledgment;132
12.9;References;132
13;Antioxidants in Chemoprevention of Skin Cancer;137
13.1;Skin Cancer Development and Antioxidants;138
13.2;Skin Cancer Chemoprevention by NaturallyOccurring Antioxidants;139
13.3;Conclusion;146
13.4;References;147
14;Radical Reactions of Carotenoids and Potential In.uence on UV Carcinogenesis;149
14.1;Radical Reactions of Carotenoids;151
14.2;Epidemiologica
2;Preface;9
3;Detection of Free Radicals in Skin: A Review of the Literature and New Developments;10
3.1;Direct Detection of Free Radicals;11
3.2;Indirect Detection of Free Radicals;11
3.3;Nitroxide-Based Electron Paramagnetic Resonance;12
3.4;Electron Paramagnetic Resonance Imaging;16
3.5;In vivo Electron Paramagnetic Resonance;17
3.6;Outlook;21
3.7;References;21
4;Electron Paramagnetic Resonance Detection of Free Radicals in UV-Irradiated Human and Mouse Skin;27
4.1;Materials and Methods;28
4.2;Results;28
4.3;Discussion;31
4.4;References;32
5;The Antioxidant Network of the Stratum corneum;35
5.1;Physiological Levels of Antioxidants in the Stratum corneum;35
5.2;Impact of Environmental Factors on Barrier-Antioxidants;37
5.3;Clinical Implications of Oxidative Stress in the Stratum corneum;43
5.4;Synopsis;48
5.5;Acknowledgements;49
5.6;References;49
6;Activity of Alpha-Lipoic Acid in the Protection against Oxidative Stress in Skin;52
6.1;Materials and Methods;53
6.2;Results and Discussion;54
6.3;Conclusion;58
6.4;Acknowledgments;58
6.5;References;59
7;Ozone: An Emerging Oxidative Stressor to Skin;61
7.1;O3 Reacts in the Stratum corneum;61
7.2;O3 Depletes Hydrophilic Antioxidants;63
7.3;O3-Induces Damage to Biomolecules;63
7.4;O3 and UV Radiation Have Additive Effects;65
7.5;Potential Pathophysiological Consequences of Topical O3 Exposure;66
7.6;Conclusion;68
7.7;References;68
8;Effects of UV and Visible Radiations on Cellular DNA;71
8.1;DNA Photoproducts Arising from Direct UVB Excitation;72
8.2;UVA- and Visible-Radiation-Mediated Oxidative Damage to DNA;74
8.3;Measurement of UVA- and Visible-Light-Mediated Formation of Oxidized Bases and Strand Breaks within Cellular DNA;77
8.4;Conclusions and Future Directions;79
8.5;References;80
9;Sequence-Specific DNA Damage Induced by UVA Radiation in the Presence of Endogenous and Exogenous Photosensitizers;83
9.1;Type I Mechanism;85
9.2;Major Type II Mechanism;88
9.3;Minor Type II Mechanism;89
9.4;Role of UVA-Induced Oxidative DNA Damage in Mutagenesis;89
9.5;References;90
10;UV-Induced Oxidative Stress and Photoaging;92
10.1;Clinical and Biochemical Features in Photoaging;93
10.2;UV-Generated Oxidative Stress Drives Photoaging;94
10.3;UV-Induced Reactive Oxygen Species and Their Damaging Effect on Structural Dermal Proteins;95
10.4;UV-Induced Reactive Oxygen Species and Their Damaging Effects on the Cellular Component of Dermal Connective Tissue;98
10.5;Perspectives;100
10.6;References;100
11;UVA and Singlet Oxygen as Inducers of Cutaneous Signaling Events;104
11.1;Generation of Singlet Oxygen in vivo;105
11.2;Singlet Oxygen as Mediator of UVA-Induced Signaling;108
11.3;Signaling Induced by Photodynamic Therapy;111
11.4;UVA, PDT, Singlet Oxygen and Apoptosis;113
11.5;Conclusion;116
11.6;Acknowledgements;116
11.7;References;116
12;Reactive Oxygen Species as Mediators of UVB-Induced Mitogen-Activated Protein Kinase Activation in Keratinocytes;123
12.1;Mitogen-Activated Protein Kinases Induced by UVB;124
12.2;Reactive Oxygen Species: Mediators of UVB-Induced Mitogen-Activated Protein Kinase Activation;126
12.3;Antioxidants in the Regulation of UVB-Induced Mitogen-Activated Protein Kinase Activation;128
12.4;Role of UVB-Induced Extracellular Signal-Regulated Kinase Activation in Cell Survival;129
12.5;Mitogen-Activated Protein Kinase Activation: Dependence on Epidermal Growth Factor Receptor Phosphorylation;130
12.6;Phosphatases: Regulators of Mitogen-Activated Protein Kinase;131
12.7;Perspective;132
12.8;Acknowledgment;132
12.9;References;132
13;Antioxidants in Chemoprevention of Skin Cancer;137
13.1;Skin Cancer Development and Antioxidants;138
13.2;Skin Cancer Chemoprevention by NaturallyOccurring Antioxidants;139
13.3;Conclusion;146
13.4;References;147
14;Radical Reactions of Carotenoids and Potential In.uence on UV Carcinogenesis;149
14.1;Radical Reactions of Carotenoids;151
14.2;Epidemiologica