Oxidative Tissue Injury in Experimental Models of Multiple Sclerosis - Schuh, Cornelia
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Multiple sclerosis (MS) is a chronic disease of the central nervous system. A number of different animal models of MS contributed to a better understanding of MS pathology. Additionally, experimental models enabled the development of immune-modulatory therapies for MS patients. In recent years, growing evidence for a major role of oxidative injury in demyelination and neurodegeneration in MS has been emerging. Hence, we aimed to characterise the nature and the extent of oxidative damage in different experimental models in comparison to MS. For this purpose, we emphasised the expression of…mehr

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Produktbeschreibung
Multiple sclerosis (MS) is a chronic disease of the central nervous system. A number of different animal models of MS contributed to a better understanding of MS pathology. Additionally, experimental models enabled the development of immune-modulatory therapies for MS patients. In recent years, growing evidence for a major role of oxidative injury in demyelination and neurodegeneration in MS has been emerging. Hence, we aimed to characterise the nature and the extent of oxidative damage in different experimental models in comparison to MS. For this purpose, we emphasised the expression of enzymes involved in reactive species production and the accumulation of oxidised phospholipids and iron, which is a potential amplifier of oxidative damage. The different animal models were triggered by diverse inflammatory mechanisms, each representing distinct aspects of MS pathology. The presented study reports a diverging extent of oxidative injury and underlying mechanisms in different models for inflammatory demyelination.
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Autorenporträt
Cornelia Schuh, PhD; Postdoc at the Paracelsus Medical University in Salzburg in the Institute of Experimental and Clinical Cell Therapy; PhD study at the Medical University of Vienna in the Centre for Brain Research, Supervisor: Univ. Prof. Dr. Hans Lassmann; Studies of Molecular Biology at the University of Vienna