The International Society on OXygen Transport to Tissue (ISO'IT) has canpleted nine years as a society since its first fonnal meeting at Charleston-Clanson, South Carolina, United States of America in 1973. Prior to this time an active group of scientists and engineers rret in w::rkshop environrrents, on a periodic basis, around the w::rld. Meetings are ncM on an annual basis, alternating between Europe and the United States. The international gatherings include scientists and engineers in a variety of fields. ISOIT has produced a stable forum for the exchange of info:rmation on the…mehr
The International Society on OXygen Transport to Tissue (ISO'IT) has canpleted nine years as a society since its first fonnal meeting at Charleston-Clanson, South Carolina, United States of America in 1973. Prior to this time an active group of scientists and engineers rret in w::rkshop environrrents, on a periodic basis, around the w::rld. Meetings are ncM on an annual basis, alternating between Europe and the United States. The international gatherings include scientists and engineers in a variety of fields. ISOIT has produced a stable forum for the exchange of info:rmation on the rnicroenvirornnent of living cells, ranging fran the utilization of mathematics and engineering, through physiology and radiobiology, to clinical applications. The proceedings of these meetings have been codified into six books, four of them published by Plenum Press in its prestigious Advances in Experimental Medicine and Biology series. This volume, together with the next two volumes that will follCJV.l the meetings in Dortmund, Gennany in 1982 and in Ruston, Louisiana in 1983 will provide further chapters in the history of this fascinating field of knCJV.lledge. OUr thanks are given to all the participants and contributors to the Detroit meeting. We hope that the strength of the society will grow in caning years, and that our contribution will eventually be felt in :inproving the treatment of the sick, and in enhancing the thought processes of the intellectual.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
The Transport of Oxygen, Glucose, Carbon Dioxide and Lactic Acid in the Human Brain: Mathematical Models.- Incomplete Cerebral Ischemia in the Rat: Vascular and Metabolic Changes as Measured by Infrared Transillumination In Vivo.- Hypoxia and the Radiation Response of Tumors.- Maternal and Fetal Tissue PO2 in the Pregnant Ewe Measured with Galvanic PO2 Electrodes.- The Use of a Peroxidase Electrode to Measure the Effects of Nitro Compounds on Intact Cells.- Simulation of Skin Oxygen Supply with Heat Induced Hyperemia.- Calculating CO2 Partial Pressure Fields Within the Upper Skin (Capillary Loop Model).- Disposable Solid State Oxygen Sensor.- Spectrophotometric Investigation of Pulsatile Blood Flow for Transcutaneous Reflectance Oximetry.- Oxygen Indicator Dilution Curves of the Canine Cerebral Circulation.- Quantitative Analysis of Reflection Spectra on the Perfused Brain in Different States of Oxygen Supply.- Correlation of Brain NADH Redox State, K+, PO2 and Electrical Activity During Hypoxia, Ischemia and Spreading Depression.- Multisite Measurements of NADH Redox State from Cerebral Cortex of the Awake Animal.- Dynamics of Cerebrovascular Responses to Oxygen.- Cerebrovascular Responses to Oxygen During Barbiturate Anesthesia.- Local PO2 and Unit Activity Measured with an Oxygen Microelectrode from the Gerbil Cerebral Cortex During Seizure and EEG Suppression.- Vascular Wall PO2 Following Carbon Monoxide Exposure.- Evidence for the Blood Oxygen Boundary Layer pO2 Gradient (?pO2) as a Significant Determinant of Intimal (PW) and Lowest Medial pO2 (p?n) in the Vivo Dog Femoral Artery.- Delayed Recovery Following Hypothermic Arrest in Rabbit Myocardium.- The Effect of Hypoxic and Histotoxic Hypoxia on Contractility and Blood Flow of the Langendorff Guinea Pig HeartPreparation.- Concomitant Reduction in Uterine Blood Flaw and Intrauterine Oxygen Tension in the Rat Following Nicotine Administration.- Capillary Supply and Utilization of Intracellular Oxygen in the Left Ventricular Myocardium from Rats Adapted to High Altitude.- The Krogh Cylinder Geometry is Not Appropriate for Modelling O2 Transport in Contracted Skeletal Muscle.- Skeletal Muscle Surface Oxygen Pressure Fields in Farly Myocardial Infarction: A Preliminary Report on the Effects of Nitroglycerine and Oxygen Breathing.- 31P NMR Spectroscopy of Brain and Heart.- Metabolic Effects of Lowering Oxygen Tension In Vivo.- Phosphorus NMR Spectroscopy of Cat Biceps and Soleus Muscles.- Lactate Production in a Pure Red Muscle in Absence of Anoxia: Mechanisms and Significance.- Cyanide Insensitive Respiration in Mammalian Cells: An Artifact of Mycoplasmal Contamination.- Factors Influencing the Oxygen Consun!ption and Radiation Response of Cultured Mammalian Cells.- Inhibition of Cultured Human Tumor Cell Oxygen Utilization by Chlorpromazine.- Oxygen Multistep Immnmostimulation - A New Concept for Improving the Immune State in Cancer Patients.- Interrelationship Between PO2, Morphology and Perfusion in Rat Mammary Adenocarcinoma (AD) Using Combined in Vivo Microcathode/India Ink Injection/Freeze Substitution Techniques.- Relationship Between Size and Oxygenation Status of Malignant Tumors.- A Method to Measure the Radio and Chemosensitivity of Human Spheroids.- Cellular Oxygen Utilization and Radiation Response of V-79 Spheroids.- Characterization of Oxygen-Hemoglobin Equilibrium Curves Using Nonlinear Regression of the Hill Equation: Parameter Values for Normal Human Adults.- Methodological Aspects of Microelectrôde Measurements in Cellular Spheroids.- Determination ofDiffusion Constants for Metabolites in Multicell Tumor Spheroids.- Oxygen Consumption Profiles Inside Cellular Spheroids Calculated From Po2 Profiles.- Mathematical Analysis of the Influence of Different Supply Conditions on PO2 Fields Inside Cellular Spheroids by the Aid of Finite Element Method.- Evidence for a Major Role of Glucose in Controlling Development of Necrosis in EMI6/RO Multicell Tumor Spheroids.- Frequency Distribution Histograms of Oxygen Tensions in Multicell Spheroids.- Estimation of the Rate of CO2 Diffusion Into the Red Cell Through the Bohr Shift.- DPG - A Link Between Blood Acid-Base Status and Respiratory Function.- O2 Uptake and Release by Red Cells Through Plasma Layer and Capillary Wall.- Measurements of Oxygen Transport in Single Capillaries.- Diffusion of Carbon Dioxide in Blood Protein Solutions.- Analysis of the Interrelationships of Non-Nutrient Blood Flow, Oxygen Delivery, Oxygen Consumption, and the Ratio of Oxygen Delivery/Oxygen Consumption Based on a Mathematical Model of Non-Nutrient Blood Flow.- Coronary Conductivity and Tissue Oxygenation as Measured by the Myoglobin O2 Saturation and the Cytochrome AA3 Redox State in the Langendorff Guinea Pig Heart Preparation.- Temporal Correlation Between Intrauterine Oxygen Tension and Endometrial H4-Lactic Dehydrogenase in the Guinea Pig.- Responses of the "Hypoxic Resistant" R15 Neuron of Aplysia to Reduced Extracellular Oxygen Tensions.- The Theoretical Prediction of Substrate Levels and Their Histograms in Cell Free Perfused Tissues.- Direct Measurement of Intracellular O2 Gradients; Role of Convection and Myoglobin.- Changes in Tissue Oxygenation and Acidity Induced by Localized Microwave Hyperthermia and Hematoporphyrin Phototherapy, an Update.
The Transport of Oxygen, Glucose, Carbon Dioxide and Lactic Acid in the Human Brain: Mathematical Models.- Incomplete Cerebral Ischemia in the Rat: Vascular and Metabolic Changes as Measured by Infrared Transillumination In Vivo.- Hypoxia and the Radiation Response of Tumors.- Maternal and Fetal Tissue PO2 in the Pregnant Ewe Measured with Galvanic PO2 Electrodes.- The Use of a Peroxidase Electrode to Measure the Effects of Nitro Compounds on Intact Cells.- Simulation of Skin Oxygen Supply with Heat Induced Hyperemia.- Calculating CO2 Partial Pressure Fields Within the Upper Skin (Capillary Loop Model).- Disposable Solid State Oxygen Sensor.- Spectrophotometric Investigation of Pulsatile Blood Flow for Transcutaneous Reflectance Oximetry.- Oxygen Indicator Dilution Curves of the Canine Cerebral Circulation.- Quantitative Analysis of Reflection Spectra on the Perfused Brain in Different States of Oxygen Supply.- Correlation of Brain NADH Redox State, K+, PO2 and Electrical Activity During Hypoxia, Ischemia and Spreading Depression.- Multisite Measurements of NADH Redox State from Cerebral Cortex of the Awake Animal.- Dynamics of Cerebrovascular Responses to Oxygen.- Cerebrovascular Responses to Oxygen During Barbiturate Anesthesia.- Local PO2 and Unit Activity Measured with an Oxygen Microelectrode from the Gerbil Cerebral Cortex During Seizure and EEG Suppression.- Vascular Wall PO2 Following Carbon Monoxide Exposure.- Evidence for the Blood Oxygen Boundary Layer pO2 Gradient (?pO2) as a Significant Determinant of Intimal (PW) and Lowest Medial pO2 (p?n) in the Vivo Dog Femoral Artery.- Delayed Recovery Following Hypothermic Arrest in Rabbit Myocardium.- The Effect of Hypoxic and Histotoxic Hypoxia on Contractility and Blood Flow of the Langendorff Guinea Pig HeartPreparation.- Concomitant Reduction in Uterine Blood Flaw and Intrauterine Oxygen Tension in the Rat Following Nicotine Administration.- Capillary Supply and Utilization of Intracellular Oxygen in the Left Ventricular Myocardium from Rats Adapted to High Altitude.- The Krogh Cylinder Geometry is Not Appropriate for Modelling O2 Transport in Contracted Skeletal Muscle.- Skeletal Muscle Surface Oxygen Pressure Fields in Farly Myocardial Infarction: A Preliminary Report on the Effects of Nitroglycerine and Oxygen Breathing.- 31P NMR Spectroscopy of Brain and Heart.- Metabolic Effects of Lowering Oxygen Tension In Vivo.- Phosphorus NMR Spectroscopy of Cat Biceps and Soleus Muscles.- Lactate Production in a Pure Red Muscle in Absence of Anoxia: Mechanisms and Significance.- Cyanide Insensitive Respiration in Mammalian Cells: An Artifact of Mycoplasmal Contamination.- Factors Influencing the Oxygen Consun!ption and Radiation Response of Cultured Mammalian Cells.- Inhibition of Cultured Human Tumor Cell Oxygen Utilization by Chlorpromazine.- Oxygen Multistep Immnmostimulation - A New Concept for Improving the Immune State in Cancer Patients.- Interrelationship Between PO2, Morphology and Perfusion in Rat Mammary Adenocarcinoma (AD) Using Combined in Vivo Microcathode/India Ink Injection/Freeze Substitution Techniques.- Relationship Between Size and Oxygenation Status of Malignant Tumors.- A Method to Measure the Radio and Chemosensitivity of Human Spheroids.- Cellular Oxygen Utilization and Radiation Response of V-79 Spheroids.- Characterization of Oxygen-Hemoglobin Equilibrium Curves Using Nonlinear Regression of the Hill Equation: Parameter Values for Normal Human Adults.- Methodological Aspects of Microelectrôde Measurements in Cellular Spheroids.- Determination ofDiffusion Constants for Metabolites in Multicell Tumor Spheroids.- Oxygen Consumption Profiles Inside Cellular Spheroids Calculated From Po2 Profiles.- Mathematical Analysis of the Influence of Different Supply Conditions on PO2 Fields Inside Cellular Spheroids by the Aid of Finite Element Method.- Evidence for a Major Role of Glucose in Controlling Development of Necrosis in EMI6/RO Multicell Tumor Spheroids.- Frequency Distribution Histograms of Oxygen Tensions in Multicell Spheroids.- Estimation of the Rate of CO2 Diffusion Into the Red Cell Through the Bohr Shift.- DPG - A Link Between Blood Acid-Base Status and Respiratory Function.- O2 Uptake and Release by Red Cells Through Plasma Layer and Capillary Wall.- Measurements of Oxygen Transport in Single Capillaries.- Diffusion of Carbon Dioxide in Blood Protein Solutions.- Analysis of the Interrelationships of Non-Nutrient Blood Flow, Oxygen Delivery, Oxygen Consumption, and the Ratio of Oxygen Delivery/Oxygen Consumption Based on a Mathematical Model of Non-Nutrient Blood Flow.- Coronary Conductivity and Tissue Oxygenation as Measured by the Myoglobin O2 Saturation and the Cytochrome AA3 Redox State in the Langendorff Guinea Pig Heart Preparation.- Temporal Correlation Between Intrauterine Oxygen Tension and Endometrial H4-Lactic Dehydrogenase in the Guinea Pig.- Responses of the "Hypoxic Resistant" R15 Neuron of Aplysia to Reduced Extracellular Oxygen Tensions.- The Theoretical Prediction of Substrate Levels and Their Histograms in Cell Free Perfused Tissues.- Direct Measurement of Intracellular O2 Gradients; Role of Convection and Myoglobin.- Changes in Tissue Oxygenation and Acidity Induced by Localized Microwave Hyperthermia and Hematoporphyrin Phototherapy, an Update.
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