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Endocrine Disruption Chemicals (EDCs) are persistent against conventional wastewater treatment method. It was ascertained that ozone can effectively degrade and mineralize most of the EDCs. For this, ozonolysis of a model EDC, Diclofenac sodium (DFS) has been carried out in sami-batch process to get necessary kinetics. With this, a simulation model has been developed for flow ozone membrane reactor. Because this reactor can simultaneously mineralize and separate EDCs effectively from water and wastewater. Afterwards a model simulation has been carried out for ozone membrane reactor to predict its performance. Model simulation predicted mineralization of EDC (DFS) from water and wastewater. This work will be helpful for water treatment industries to develop suitable membrane (i.e., characteristic parameters of membrane such as efficiency, molecular weight cut-off and enhancement) to treat EDCs from water and wastewater.