p16INK4A gene mutations in Esophageal Squamous Cell Carcinoma - Qureshi, Meenu;Andrabi, Khurshid
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This monogram describes a pattern of p16INK4A variants with potential to associate with esophageal squamous cell carcinoma in a high risk ethnic population from Kashmir, India. A novel frame shifting deletion mutation that brings about premature transcript termination has been characterized. The monogram also describes the functional implications associated with this founder mutation which may have a significant impact in contributing to the genesis of esophageal squamous cell carcinoma, in addition of its significant diagnostic relevance.

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Produktbeschreibung
This monogram describes a pattern of p16INK4A variants with potential to associate with esophageal squamous cell carcinoma in a high risk ethnic population from Kashmir, India. A novel frame shifting deletion mutation that brings about premature transcript termination has been characterized. The monogram also describes the functional implications associated with this founder mutation which may have a significant impact in contributing to the genesis of esophageal squamous cell carcinoma, in addition of its significant diagnostic relevance.
Autorenporträt
Dr. Meenu Qureshi, a post doctoral fellow at the Department of Biotechnology, University of Kashmir is involved in investigating the role of cell cycle machinery in dysregulated pattern of multiplication associated with various human cancers, particularly esophageal cancer.