Dental pain is one of the main reasons for a patient to visit an endodontist. Man-agement of dental pain with anxiety during and after treatment remains a big challenge and a clinician's skills are often judged primarily by the success or failure of pain control. Hence, abundant knowledge of mechanism of pain and different techniues for managing pain is of utmost importance for an Endodontist. This book is a brief review about different pharmacological as well as non pharmacological approaches for managing Pain during pre , intra as well as post endodontic treatment.