High Quality Content by WIKIPEDIA articles! Palo Alto is a California charter city located in the northwest corner of Santa Clara County, in the San Francisco Bay Area of California, USA. It is named after a tree called El Palo Alto. The city includes portions of Stanford University and is headquarters to a number of Silicon Valley high-technology companies, including Hewlett-Packard, VMware and Facebook. As of the 2000 census, the city had a total population of 58,598 residents.