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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Pancreatitis is inflammation of the pancreas. The pancreas is central in the pathophysiology of both major types of diabetes mellitus. In type 1 diabetes mellitus, there is direct damage to the endocrine pancreas that results in insufficient insulin synthesis and secretion. Type 2 diabetes mellitus, which begins with insulin resistance, is characterized by the ultimate failure of pancreatic cells to match insulin production with insulin demand.