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Human papillomaviruses (HPV) are among the most widespread sexually transmitted infections: around 70-80% of the sexually active population will come into contact with these viruses during their sexual lives.The p53 protein is a transcription factor that plays an important role in cancer, controlling the cell cycle and interacting with dozens of genes. Viral oncogenesis is a multi-step process, largely dependent on the complex interaction between viruses and host factors.