Parkinson's Disease

Current and Future Therapeutics and Clinical Trials
Herausgeber: Espay, Alberto; Galvez-Jimenez, Nestor; Fernandez, Hubert

• Gebundenes Buch

Produktbeschreibung

Parkinson's disease is no longer considered only a motor disorder. It has become evident that the pathological changes are broad, the progression seems to follow a pattern suggesting transynaptic transmission via templation of proteins in a prion-like fashion, and that these pathological changes usually antedate the motor symptoms by decades. This book emphasizes treatment options for Parkinson's disease, critically assessing pharmacologic and surgical interventions for all aspects of the disease. Evidence from randomized controlled clinical trials is highlighted to develop practical recommendations for clinical practice. Lessons learnt from clinical trials - and controversies and future challenges - are all addressed. Readers will find the necessary clinical and scientific foundations for the understanding of the disease, the underpinnings of the pathological processes, the identification of disease biomarkers, and the basis for solid therapeutics. Chapters are authored by an international team of specialists who bring their expertise to improving the management of this disease.

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Produktdetails

• Verlag: Cambridge University Press
• Seitenzahl: 388
• Erscheinungstermin: 24. März 2016
• Englisch
• Abmessung: 260mm x 208mm x 25mm
• Gewicht: 1052g
• ISBN-13: 9781107053861
• ISBN-10: 1107053862
• Artikelnr.: 44263399

Inhaltsangabe

Part I. The Pharmacological Basis for Parkinson's Disease Treatment: 1. The
pharmacological basis of Parkinson's disease therapy: an overview; 2.
Anticholinergic agents in the management of Parkinson's disease; 3.
Amantadine and antiglutamatergic drugs in the management of Parkinson's
disease; 4. Monoamine oxidase inhibitors in the management of Parkinson's
disease; 5. Oral dopamine agonists in the anagement of Parkinson's disease;
6. Subcutaneous, intranasal and transdermal dopamine agonists in the
management of Parkinson's disease; 7. Oral and infusion levodopa therapy in
the management of Parkinson's disease; 8. Catechol-O-methyltransferase
inhibitors in the management of Parkinson's disease; 9. Experimental
pharmacological agents in the management of Parkinson's disease; Part II.
Management of Non-Motor Symptoms of Parkinson's Disease: 10. Management of
autonomic dysfunction in Parkinson's disease; 11. Management of cognitive
impairment in Parkinson's disease; 12. A neurobehavioralist approach to the
management of cognitive impairment in Parkinson's disease; 13. Management
of disease-related behavioral disturbances in Parkinson's disease; 14.
Management of treatment-related behavioral disturbances in Parkinson's
disease; 15. Management of sleep disorders in Parkinson's disease; 16.
Management of pain and euromuscular complications in Parkinson's disease;
Part III. Surgical Management of Parkinson's Disease: 17. Thalamotomy,
pallidotomy and subthalamotomy in the management of Parkinson's disease;
18. Deep brain stimulation of the globus pallidus internus in the
management of Parkinson's disease; 19. Deep brain stimulation of the
subthalamic nucleus in the management of Parkinson's disease; 20. Deep
brain stimulation of the thalamic ventral intermediate nucleus in the
management of Parkinson's disease; 21. Emerging targets and other
stimulation-related procedures in the management of Parkinson's disease;
Part IV. Clinical Trials in Parkinson's Disease: Lessons, Controversies and
Challenges: 22. Rating scales and clinical outcome measures in the
evaluation of patients with Parkinson's disease; 23. Functional imaging
markers as outcome measures in clinical trials for Parkinson's disease; 24.
Cerebrospinal fluid and blood biomarkers as outcome measures in clinical
trials for Parkinson's disease; 25. Lessons learned: neuroprotective trials
in Parkinson's disease; 26. Lessons learned: symptomatic trials in early
Parkinson's disease; 27. Controversy: GPi vs STN deep brain stimulation in
the management of Parkinson's disease; 28. Controversy: ablative surgery vs
deep brain stimulation in the management of Parkinson's disease; 29.
Controversy: mid-stage vs advanced stage deep brain stimulation in the
management of Parkinson's disease; 30. Lessons and challenges of trials for
cognitive and behavioral complications of Parkinson's disease; 31. Lessons
and challenges of trials for other non-motor complications of Parkinson's
disease; 32. Lessons and challenges of trials involving ancillary therapies
for the management of Parkinson's disease; Index.