Parkinson's Disease

Genetics and Pathogenesis
Herausgeber: Dawson, Ted M

• Broschiertes Buch

Produktbeschreibung

The first authoritative collection of recent breakthroughs in Parkinson's disease (PD) research, this reference spans key findings on the mechanisms of neurodegeneration and the role of specific genes that may lead to improved therapies for PD. This guide will review the major aspects of the disease including motoric and pathologic features, and autonomic dysfunction, sleep disorders, and neuropsychiatric manifestations, as well as provide an in-depth review of genetic considerations. With contributions by recognized experts on the topic, this source will address the pathogenesis, experimental models, future therapeutic opportunities, and research trends affecting the field.

Produktdetails

• Verlag: Longman Publishing Group
• Seitenzahl: 404
• Erscheinungstermin: 5. September 2019
• Englisch
• Abmessung: 226mm x 150mm x 23mm
• Gewicht: 771g
• ISBN-13: 9780367389154
• ISBN-10: 0367389150
• Artikelnr.: 57732909

Autorenporträt

Ted M. Dawson

Inhaltsangabe

OVERVIEW. Neuropathology and Staging of Parkinson's Disease. Genetics of
Parkinson's Disease. Epidemiology of Parkinson's Disease. Treatment of
Parkinson's Disease. GENETICS. Genetics of Alpha-Synuclein. Clinical and
Genetic Features of PARKIN-Related Parkinson's Disease. DJ-1 in Parkinson's
Disease. PINK1 Parkinsonism. LRRK2. Genetics of Tau in Parkinsonism.
Genetic Risk Factors for PD.
PATHOGENESIS. Alpha-Synuclein and Parkinson's Disease. Tau in Parkinson's
Disease.
The Role of PARKIN in Parkinson's Disease. Mitochondrial Complex I
Deficiency in Parkinson's Disease: A Mechanism for Oxidant-Based
Pathogenesis. The Ubiquitin-Proteasome System in Parkinson's Disease.
ANIMAL MODELS. Transgenic Models of Alpha-Synucleinopathy. Mouse Models of
Recessive Parkinsonism. Drosophila Models of Parkinson's Disease. C.
Elegans Models of Parkinson's Disease. The MPTP Model of Parkinson's
Disease. Rotenone Model. Drug Trials in Animal Models of PD