In this book we tried to evaluate effect of traditional chemotherapy on cell line of Multiple myeloma(MM), and compare it with effect of combination (chemotherapeutic plus paroxetine) in cell line of MM. The addition of paroxetine to the standard chemotherapy that is supplied to the Multiple myeloma patients may have a promising effect in enhancing the therapeutic strength of standard chemotherapy. The use of standard chemotherapy alone has null effect in treatment of the disease even though it halted the disease progression, according to the biochemical parameters measured.