In Prehistoric times before writing, wild buffaloes may have lived in Mesopotamia while in the pre-Christian centuries there may been movements of domestic animals from the Indus Valley. Archeological remains of cylindrical seals and ivory materials where discovered in Ur at Royal cemetery especially the black marbled seal contains artifacts depicting Gilgamesh with water buffaloes in the rivers of the Tigris and Euphrates with typical crescent horn of two male swamp buffaloes. Pasteurella multocida, is a Gram negative pathogenic bacteria, and it can produce many types of diseases to many species of animals. Hemorrhagic septicemia(HS) are important economic disease caused by Pasteurella multocida because it is fatal to buffaloes in many cases.