This book is the first publication to provide comprehensive guidance regarding the identification, characterization, and interpretation of mouse developmental defects. It emphasizes the interpretation of abnormal phenotypes and provides detailed protocols for appropriately processing mouse embryos, fetuses, neonates, juveniles, and placentas. A complete reference on the design, analysis, and interpretation of abnormal findings, the book is enhanced with numerous full-color illustrations, enabling readers to comprehend both normal development and the major categories of defects that may be seen…mehr
This book is the first publication to provide comprehensive guidance regarding the identification, characterization, and interpretation of mouse developmental defects. It emphasizes the interpretation of abnormal phenotypes and provides detailed protocols for appropriately processing mouse embryos, fetuses, neonates, juveniles, and placentas. A complete reference on the design, analysis, and interpretation of abnormal findings, the book is enhanced with numerous full-color illustrations, enabling readers to comprehend both normal development and the major categories of defects that may be seen in malformed developing mice (and placentas) of all ages. The extensive literature citations provide a starting point for additional reading to begin building true expertise in the field.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Brad Bolon, DVM, MS, PhD, is a Diplomate of both the American College of Veterinary Pathologists (DACVP) and the American Board of Toxicology (DABT) as well as a Fellow of both the Academy of Toxicological Sciences (FATS) and the International Academy of Toxicologic Pathology (FIATP). He is currently an associate professor in the Department of Veterinary Biosciences, College of Veterinary Medicine and also the associate director of the Comparative Pathology and Mouse Phenotyping Shared Resource, Comprehensive Cancer Center at the Columbus campus of The Ohio State University (OSU). His main professional interests are the pathology of genetically engineered mice (especially embryos, fetuses, neonates, and placentas) and toxicologic neuropathology.
Inhaltsangabe
INTRODUCTION. The Case for Developmental Pathology and Developmental Pathologists. FUNDAMENTALS OF MOUSE DEVELOPMENTAL BIOLOGY. Essentials of Mouse Genetics and Nomenclature. Essential Terminology for Mouse Developmental Pathology Studies. Anatomy and Physiology of the Developing Mouse and Placenta. Teratogens and Teratogenic Mechanisms in Mouse Developmental Pathology. EXPERIMENTAL METHODS IN MOUSE DEVELOPMENTAL PATHOLOGY. Principles of Experimental Design for Mouse Developmental Pathology Studies. Necropsy Sampling and Data Collection for Studying the Anatomy, Histology, and Pathology of Mouse Development. Clinical Pathology Analysis in Developing Mice. Histotechnological Processing of Developing Mice. Localization of Gene Expression in Developing Mice. Protein Localization in Developing Mice. Quantitative Morphological Assessment in Mouse Developmental Pathology Studies. Ultrastructural Evaluation of Developing Mice. Three-Dimensional Imaging in Mouse Developmental Pathology Studies. ANALYTICAL PRACTICES FOR MOUSE DEVELOPMENTAL PATHOLOGY. Pathology of the Developing Mouse from Conception to Weaning. Pathology of the Placenta. Mouse Developmental Pathology Assessments in High-Throughput Phenogenomic Facilities. A Statistical Analysis Primer for Mouse Developmental Pathology Studies. COMMON ABBREVIATIONS IN MOUSE DEVELOPMENTAL PATHOLOGY STUDIES. INDEX.
INTRODUCTION. The Case for Developmental Pathology and Developmental Pathologists. FUNDAMENTALS OF MOUSE DEVELOPMENTAL BIOLOGY. Essentials of Mouse Genetics and Nomenclature. Essential Terminology for Mouse Developmental Pathology Studies. Anatomy and Physiology of the Developing Mouse and Placenta. Teratogens and Teratogenic Mechanisms in Mouse Developmental Pathology. EXPERIMENTAL METHODS IN MOUSE DEVELOPMENTAL PATHOLOGY. Principles of Experimental Design for Mouse Developmental Pathology Studies. Necropsy Sampling and Data Collection for Studying the Anatomy, Histology, and Pathology of Mouse Development. Clinical Pathology Analysis in Developing Mice. Histotechnological Processing of Developing Mice. Localization of Gene Expression in Developing Mice. Protein Localization in Developing Mice. Quantitative Morphological Assessment in Mouse Developmental Pathology Studies. Ultrastructural Evaluation of Developing Mice. Three-Dimensional Imaging in Mouse Developmental Pathology Studies. ANALYTICAL PRACTICES FOR MOUSE DEVELOPMENTAL PATHOLOGY. Pathology of the Developing Mouse from Conception to Weaning. Pathology of the Placenta. Mouse Developmental Pathology Assessments in High-Throughput Phenogenomic Facilities. A Statistical Analysis Primer for Mouse Developmental Pathology Studies. COMMON ABBREVIATIONS IN MOUSE DEVELOPMENTAL PATHOLOGY STUDIES. INDEX.
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