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The book entitled Pathophysiology of Orthopedic-traumatic Diseases represents the English version, with modifications and additions, of the university course entitled Fiziopatologia Afec iunilor Ortopedico-traumatice, autor Bogdan-Alexandru Hagiu, 2020, Editura Universitatii "Alexandru Ioan Cuza" University from Ia i, România. It includes elements of pathophysiology and semiology of musculoskeletal disorders that promote muscle tears, fractures, sprains and dislocations. Spinal cord injuries are also presented, as well as the signs of neurological disorders that are integrated into the pathophysiology of injuries. The book is adequate for the formation of the therapeutic conduct of future specialists.