Cancers threaten an individual's life. Cancer begins when a cell breaks free from the normal restraints on cell division and begins to follow its own agenda for proliferation. The fundamental abnormality resulting in the development of cancer is the continual unregulated proliferation of cancer cells. Tumor suppressor genes encode many kinds of proteins that help control cell growth and proliferation; mutations in these genes can contribute to the development of cancer. In many tumors, these genes are lost or inactivated, thereby removing negative regulators of cell proliferation and contributing to the abnormal proliferation of tumor cells. The problem is: How will we make tumor suppressor genes work to avoid cancers?